Protein Alignment aux and sel-5

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_001022562.1
• Gene: sel-5 / 175599
• WormBaseID: WBGene00004762
• Length: 1077
• Species: Caenorhabditis elegans
• Alignment Length: 1252
• Identity: 278/1252 - (22%)
• Similarity: 399/1252 - (31%)
• Gaps: 480/1252 - (38%)

  Fly    10 LNYFSSSEVNGAAGNGAPEALGGR-------LDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVA 67
            |..|||.:.........|   ||:       .:|...|..:::...|:.|:..|||||:|.||||
 Worm     3 LGLFSSGKAQVLCDEKIP---GGKKKEPKQLSENKCKGVTLKLDHTRVTIEKQIAEGGFAIVYVA 64

  Fly    68 QDVQTGTEYALKRLIGADMQAS-TAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLT 131
            .| :...::||||....|.:.. .|...|.:..||..||:|||.|| .|||.
 Worm    65 SD-RKNNKFALKRQFTKDNEKQLEACCREHSFLKQCIGHKNIVEFV-DSYTN------------- 114

  Fly   132 ELCKGGSLVDC-----------------------FRTNNAPFNPTCVLRIFYQMARAVASLHSQS 173
              |.|..:.:|                       :.||:.      :|.||..:..||:.:|::.
 Worm   115 --CLGNGIWECMLLTEYHQKNVLQLMNERISQNQYLTNDE------ILSIFTDLCEAVSFIHNRP 171

  Fly   174 PPIAHRDIKIENFLIGNDK--QIKLCDFGSASTEVLSPT---FEWSANQRSMLEDQLNTVTTPMY 233
            .||.|||:|:||.||.:.|  ...|||||||:|::||..   .|:       ::.::...||..|
 Worm   172 QPIIHRDLKVENVLISSHKPPHYVLCDFGSATTQILSVEKYGVEY-------VKSEVERNTTMCY 229

  Fly   234 RSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKLRIINANYMLPPDPQYQCFSDII 298
            |||||:|.:|...||.|.||||||.:||.||:...|:|: ..|.|.:.||..|..|.       |
 Worm   230 RSPEMIDFYSGLEIGLKSDIWALGVLLYRLCFFCVPFEE-SPLAIQSVNYQFPSVPN-------I 286

  Fly   299 RGCLKVNPFERLDI----------TMVLEGLAALAETHNWSLKGPLDLHIM------PIESL--- 344
            ...:||..:..|||          |.||    |....|    :.||...|.      .:.||
 Worm   287 PDEIKVLIYMLLDIDVNRRPSIYQTSVL----AFEANH----RKPLSEEIQNKKCTDAVPSLKSC 343

  Fly   345 --------------------PAESPLKSSAYSEVYTEPLSAAIPSSYN-----GHGSLLSS---- 380
                                |...|::||:    ....||..:||..|     |.|::.:|
 Worm   344 IQLMRDGSNPRNKRDSSPRNPEAPPIQSSS----KMASLSQQVPSISNISMPSGSGTVETSVAPR 404

  Fly   381 LRGGAGTLLKNIKDTST---------------KVMQTMQQSLARNDLDISH---ITSRILVMP-- 425
            ||..|.|::.|:...|.               ...:|....:.:..:|..|   .:....:.|
 Worm   405 LRPKATTVVPNVPSISPVPPVGLPHLRLPSKGSTDETDGSQVRKVPIDFHHRQSFSGEEQLKPAA 469

  Fly   426 ---------CP-----------------------SDG-----------FESTYKTNNIEDVRLSL 447
                     ||                       :||           |:..:: .|:.|.....
 Worm   470 EADSAGPLSCPLIKPTDLGFTDLDKPALPRDRAQTDGKRRLPHESDIIFQQQHR-RNVSDTSQIS 533

  Fly   448 ESRFVPQKLSIYNFGQRTEPRLPPPVRTVE-------AGSVYGCPQAHAPNLQGLFTVSADMYNF 505
            .|.|.|     |:..|.|.......||:||       .||....|          |.|:....|.
 Worm   534 RSAFKP-----YSSQQTTSKTSSQVVRSVEDMSQRQNGGSGEWNP----------FLVAPFSNNS 583

  Fly   506 LNA--DPKSVVIVQTGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLY 568
            ::.  ..:|..::.....|            |..|.:|..|...::           .||...:
 Worm   584 ISRKDGQESAFMMDDSHFG------------MVFDEIRRKEIPAEL-----------DSETSSI- 624

  Fly   569 YFGDILRPTPLLPHYKNTTLVSLSCQPV--PRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRL 631
               |...|....|..:.|...|.|.|||  |..|...|           ...|||...:.||..:
 Worm   625 ---DSRDPFGAAPFDQLTVSTSSSAQPVSLPPATDEDD-----------ERQLLSETDEEEKYEI 675

  Fly   632 ---------------------------------YQAGPGKIVLPINLTACGD------------- 650
                                             |:          |:...||
 Worm   676 DEKEEIQTKKDETINEEDSEIDEQRMNDRRRYSYE----------NIDGVGDDASSDSRGKTDRD 730

  Fly   651 ----------------------VTVVLFHARKGMVRP----QGLK-------ICQF-QFNTGFIP 681
                                  ...|.....:|..||    .||:       |..| ..:|.:.|
 Worm   731 DSEEEEDDDSRRGGDTSHDEDSQNTVGSEDGEGGSRPLLEDDGLEDDDDHELISSFSSSSTNYPP 795

  Fly   682 ------EPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAV---------------TDS-----ES 720
                  .|.|....||..|.|     ::||:..::..|..               ||.     |.
 Worm   796 LFIGTSTPHTQNPITNPFLRD-----ELTPKMIITAPLPTAKNNLDDDWDLGDRWTDRRDTVFER 855

  Fly   721 PPS-HKPPWMPAKPKRSPAAL---FSSDLEYAEMLDNFVTKPSTRSSPPPGARKSDRV-SSPLVL 780
            |.| |:..:.||...|....|   |..||..|..:.  :....:.:|.|...|.||.| ..|::.
 Worm   856 PASEHQNVFAPATLPRQATPLVCRFKPDLPTAAPVS--IIPSMSNTSFPEAVRDSDTVPCEPIIG 918

  Fly   781 PDVTETAHELPSPMPEPSPPIDLLNLNQQPSDVPAA---------------------DPLT---- 820
            ..::..|...|.|.|.|..|.:.....:..:.:|.|                     |.|.
 Worm   919 TLISVGAPTDPPPPPLPKKPTEASPTQETTATIPVALGKKEKLLKKEKKKEKKDGKKDKLKLEEY 983

  Fly   821 ----SAKPSTDASFDLLGAFGDDDSTGIGSAPIPDILPPPPLQQPQPKI-NNDPFDIFGSVDQGG 880
                |::|.||.|                                :.:| .||....|.:
 Worm   984 REKGSSEPETDGS--------------------------------EAEIWTNDGATTFSN----- 1011

  Fly   881 VPSMKPSGFPPFVGSLPTFVAQPAATTNPSPTHPARASADPFANIADLATGLNLNFNRSTLSGK- 944
             ...|.|.| ....|.|:.||.....::|.|....::|.|                .:|:|:||
 Worm  1012 -KKKKKSTF-GLRSSHPSIVANDLQFSSPMPPVVKKSSKD----------------KKSSLTGKN 1058

  Fly   945 -SPVNTSPQPTQFSSPT 960
             |.||||.||.....||
 Worm  1059 ASFVNTSFQPEDHDDPT 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	106/315 (34%)
		PTP_auxilin-like	404..573	CDD:350361	34/225 (15%)
		PTEN_C2	581..711	CDD:463081	37/217 (17%)
		PHA03247	<698..1037	CDD:223021	67/320 (21%)
		Herpes_BLLF1	<882..>999	CDD:282904	24/81 (30%)
		DnaJ	<1110..1150	CDD:99751
sel-5	NP_001022562.1	STKc_NAK_like	43..320	CDD:270939	106/318 (33%)