DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aux and Bmp2k

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_542439.1	Gene:	Bmp2k / 140780	MGIID:	2155456	Length:	1138	Species:	Mus musculus

Alignment Length:	1230	Identity:	255/1230 - (20%)
Similarity:	419/1230 - (34%)	Gaps:	375/1230 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SEVNG---AAGNGAPEALGGRLDNDFVG-QVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQTGTEY 76
            ||.:|   |||..|...|||...:..:| :|..|..:::.::..:||||::.|::.: ..:|...
Mouse    10 SEGSGGGAAAGGAAGGGLGGGFASSSMGVRVFAVGRYQVTLEESLAEGGFSTVFLVR-THSGIRC 73

  Fly    77 ALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGGSLVD 141
            ||||:...:.........||.|.|:||||:|||.::..:..:.|..:. :.|:|.|.|:.|.:|:
Mouse    74 ALKRMYVNNTPDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNVW-EVLILMEYCRAGQVVN 137

  Fly   142 CFRTN-NAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTE 205
            ..... ...|..:.||:||.....|||.||....||.|||:|:||.|:.:.....|||||||:.:
Mouse   138 QMNKKLQTGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNK 202

  Fly   206 VLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPY 270
            .|:|    ..:..:::|:::...||..||:|||::.:...||..|.|||||||:||.||:...|:
Mouse   203 FLNP----QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF 263

  Fly   271 EDGGKLRIINANYMLPPDPQY----QCFSDIIRGCLKVNPFERLDITMV---------------- 315
            .: .::.|.:.::.:|.:.:|    .|   :||..|:.:|..|.||..|
Mouse   264 GE-SQVAICDGSFTIPDNSRYSHNVHC---LIRFMLEPDPECRPDIFQVSYFAFKFAKKDCPVSN 324

  Fly   316 -------------LEGLAALAETHNWSLK-----GPLDLHIMPIESLPAESPLKSSAYSEVYT-- 360
                         :....|.|.......:     ||.:..|.|.:...|.|   ::|.|.|.|
Mouse   325 INNSFLPSTLPEPMTATEAAARKSQMKARITDTIGPTETSIAPRQRPKANS---TAATSSVLTIQ 386

  Fly   361 ---EPLSAAIPSSYNGHGSLLSSLRGGAGTLLKNIK------DTSTKVMQTMQQSLARNDLDISH 416
               .|:....|..::.| ....:||.|.|:.:..::      ....:|:|.:||.
Mouse   387 SSATPVKVPAPGEFSNH-KPKGALRPGNGSEVLMVQGPPQQPPQQHRVLQQLQQG---------- 440

  Fly   417 ITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSV 481
                                     |.||        |:|.::........:.....:..:...:
Mouse   441 -------------------------DWRL--------QQLHLHRHPHHHHQQQQQQQQQQQQQQL 472

  Fly   482 YGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREPEDA 546
            ....|.....||..:                                    |..|...:.:....
Mouse   473 QQQQQQQQQLLQNAY------------------------------------LQQYQHAMHQQHIL 501

  Fly   547 VQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYME 611
            .|.|.:  |:                :.:|.|....|             |.|.:.      |.:
Mouse   502 QQQFLM--HS----------------VYQPQPPASQY-------------PAMMQQ------YQQ 529

  Fly   612 VYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHARKGMVRPQGLKICQFQFN 676
            .:....:|....|           |.:.|.|..||:..:.:..|......:....|..:......
Mouse   530 AFLQQQMLARHQQ-----------PAQQVSPEYLTSPQEFSPALVSYASSLPAQVGTIVDSSYGA 583

  Fly   677 TGFIPEPETLITFTNQ-DLDDLPDPEQVTP----RFCVSLSLAVTDSE-----------SPPSHK 725
            ...:.|.|.:..|||| .:...||.....|    .|.......:.|.|           |.||.|
Mouse   584 NRSVAEKEAVANFTNQKTISHPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLGASTPSDK 648

  Fly   726 ----PPWMPAKPKRSPAALF-------SSDLEYAEMLDN--FVTKPSTR---SSPPPGARKSDRV 774
                ||...::|...|.|..       |.:.:..|...|  .:|...|:   |||....:::.:.
Mouse   649 TVDLPPAPHSRPPEEPFASVPFISHSGSPEKKTTEHSPNQKSITANLTKNGGSSPLCKDQRAGKK 713

  Fly   775 SS--PLVLPDV------TETAHELPSPMPEPS------------------PPIDLLNLNQQPSDV 813
            :|  |::...|      :|:..|...|.|:.|                  ...:..||..:|..:
Mouse   714 TSENPVIRGQVQKGHDDSESDFESDPPSPKSSEEEQEDEDAQGEHGDFNDDDTEPENLGHRPLLM 778

  Fly   814 PAADPLTSAKPSTDASFDLLGAFGDD------DSTGIGSAPIPDILPPPPLQQPQPKIN-NDPFD 871
            .:.|.....|.|:|:..:.......|      |..|:.    ||.....|.:.|...:. :..||
Mouse   779 DSEDEEEDDKHSSDSECEQAKTKRGDTSSLRRDKPGVA----PDTALLTPARSPADALTPSQEFD 839

  Fly   872 IFGSVDQGGVPSMKPSGFPPFVGSLPTFVAQPAATTNPSP-THPARASADPFANIADLATGLNLN 935
            :||:|             |.|....|..:.......|.|. ..|.:...|.|.
Mouse   840 VFGAV-------------PFFAAPAPQSLQHRGDGKNLSQHAFPEQEDFDVFT------------ 879

  Fly   936 FNRSTLSGKSPVN--TSPQPTQFSSPTHKPSPSSQPQATFMHTPPTPQTLPSTSSIRTPTQPQAV 998
                    |:|.|  .|.|......|..:|.|:            .|:::....|  ||.||.:|
Mouse   880 --------KAPFNKKVSVQDWPAVGPDARPLPA------------RPRSVDIFGS--TPFQPFSV 922

  Fly   999 PA---QSRPD-YSRLHFDSQKAAQQPGTGGSKNSDIFADILGQQGYSFGSKMNQCPRSINEMRKE 1059
            .|   :|:.| :..:.|:....:||                 ||      |:.|  ||:.::...
Mouse   923 SASKSESKEDVFGLVPFEEITGSQQ-----------------QQ------KVKQ--RSLQKLSSR 962

  Fly  1060 DLFKDMDPKKVRIMEWTDGKKNNIRALLCSMHTVLWDNAKWQRCEMSTMVTPTEVKKAYR 1119
            ......|..|      ::||:::                          .|||..||..:
Mouse   963 QRRTKQDVSK------SNGKRHH--------------------------GTPTSAKKTLK 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357	93/310 (30%)
		S_TKc	51..317	CDD:214567	91/299 (30%)
		PTEN_C2	581..711	CDD:287393	23/134 (17%)
		DnaJ	<1110..1150	CDD:197617	5/10 (50%)
Bmp2k	NP_542439.1	STKc_NAK_like	44..317	CDD:270939	91/282 (32%)
		S_TKc	49..308	CDD:214567	90/268 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..435		18/83 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..831		39/196 (20%)
		BMP2K_C	873..1138	CDD:291930	38/209 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..1018		28/144 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1138
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1989
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D826336at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820