DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and pten

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_001116943.1	Gene:	pten / 100144716	XenbaseID:	XB-GENE-491433	Length:	402	Species:	Xenopus tropicalis

Alignment Length:	455	Identity:	111/455 - (24%)
Similarity:	188/455 - (41%)	Gaps:	112/455 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 MQQSLARN---------DLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSI 458
            :::.::||         |||:::|...|:.|..|::..|..|: |||:||...|:|:. .....|
Frog     5 IKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYR-NNIDDVVRFLDSKH-KNHYKI 67

  Fly   459 YNF-GQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSG 522
            ||. .:|.........|..:    |.....:.|.|:.:.....|:..:| ::.::|..:......
Frog    68 YNLCAERHYDTNKFSCRVAQ----YPFEDHNPPQLELIKPFCEDLDQWL-SENENVAAIHCKAGK 127

  Fly   523 GCTAATVICALLMYADLLREPEDAVQVFAVKRH------TINLRPSEFRYLYYFGDIL------R 575
            |.| ..:|||.|::.......::|:..:...|.      ||   ||:.||:||:..:|      |
Frog   128 GRT-GVMICAYLLHRGKFPRAQEALDFYGEVRTRDKKGVTI---PSQRRYVYYYSYLLKNNLEYR 188

  Fly   576 PTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLY--QAGPGK 638
            |.|||.|       .:..:.:|..:.:.          ||...::..|    |::::  .|||.:
Frog   189 PVPLLFH-------KIEFETIPMFSGST----------CNPQFVVYQL----KVKIFTSTAGPKR 232

  Fly   639 IV------LPINLTACGDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPE---------TLIT 688
            |.      .|..|..|||:.|..||.:..:::.:  |:..|..||.|||.||         ||:
Frog   233 IEKLMYFDFPQPLPVCGDIKVEFFHKQNKVMKKE--KMFHFWINTFFIPGPEEYSEKVENGTLV- 294

  Fly   689 FTNQDLDDLPDPEQVTPRFCVSLSLAVTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLDN 753
             ..|:||.:...|: :......|:|.:|.::...::|.     |..|    |||.:.:    :..
Frog   295 -GEQELDGIYSTER-SDNDKEYLTLTLTKNDLDKANKD-----KANR----LFSPNFK----VKL 344

  Fly   754 FVTKPSTRSSPPPGARKSDRVSSPLVLPDVTETAHELPSPMPEPSPPIDLLNLNQQPSDVPAADP 818
            |.||....||      .|:..||..|.|||::.         ||.        :.:.||...:||
Frog   345 FFTKTVEESS------NSEASSSTSVTPDVSDN---------EPD--------HYRYSDTTDSDP 386

Fly 819 818
Frog 387 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	33/146 (23%)
		DnaJ	<1110..1150	CDD:197617
pten	NP_001116943.1	PTP_PTEN	24..180	CDD:350359	41/166 (25%)
pten	NP_001116943.1	PTEN_C2	187..348	CDD:371036	48/199 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910