Protein Alignment beta-Man and manba

DIOPT Version :10

• Sequence 1: NP_649436.2
• Gene: beta-Man / 40524
• FlyBaseID: FBgn0037215
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: NP_956453.1
• Gene: manba / 393128
• ZFINID: ZDB-GENE-040426-721
• Length: 901
• Species: Danio rerio
• Alignment Length: 889
• Identity: 329/889 - (37%)
• Similarity: 480/889 - (53%)
• Gaps: 109/889 - (12%)

  Fly    36 VIELS-NWTITNQNGSLTIANQTLPLGIYSAFAPQ--VLDSY---NDVGLRYLAYDNFTFSNFFQ 94
            ::.|: .|.:.|.|.:.:::.: :|..:::|...|  :.|.|   ||:..|:::.||:|::..|.
Zfish    36 IVSLNGKWQLVNSNSTFSLSAE-VPGCVHTALQRQGVISDPYYRFNDLAYRWISLDNWTYTTSFS 99

  Fly    95 F--------DVHHFNRGHINLTFHGIDTVSEIRLNHQLLGRTDNMFVRYSYEVSSLLQ-AENFLE 150
            .        ||.  .:|.:.|.|.|:||:|.|.||...:|.|||||.||.::|:.||: .||.|:
Zfish   100 LPACVEEVQDVQ--GKGKVVLVFEGVDTISTISLNGVTIGTTDNMFRRYDFDVTGLLKDQENILQ 162

  Fly   151 VEIQSPVVAALARANALKEAKKSVPPECPNERYHGECHMNMLRKMQASFSWDWGPAAPSAGIWKN 215
            |.|.|.|..|..|:.|  ..|..|||:||.....||||:|.:||.|:||||||||:.|:.||||.
Zfish   163 VFIMSAVAYASQRSRA--HTKYRVPPDCPPPVQKGECHVNFIRKAQSSFSWDWGPSFPTLGIWKG 225

  Fly   216 VELEIYEVAVIREVDVDVSRVNG-SYWNMHIRCFLDAGGWQNFNGRLVLYAVELLDRPVVVDRYA 279
            |.||::....:......:...:. |.|::.:..|.|                      |||   |
Zfish   226 VRLEVFNTFRVLSFTTSLKYDSADSSWSVEVELFFD----------------------VVV---A 265

  Fly   280 IKNISHLA-PVI----EFDQAVPNGK--------------VVTWWPNGYGEQKLYPLHFTLKTWL 325
            .|.:.|:: |::    ||..::..|:              |..|||.|:|:|:||.|...:|.
Zfish   266 SKGLVHISIPLLLSEAEFQLSLTPGQRKTSFILQVNQFQNVSLWWPFGHGDQRLYNLEINVKL-- 328

  Fly   326 GPDGPEVRSKTKSHKSLR-VGFRTLDLVEDPAPDGVGNTFLFRVNGVEMFMKGSNYIPSHLLPEM 389
             .||       ::.|:.| |.|||::||::..|...|.:|.||:||..:|:||||:||.|...:.
Zfish   329 -DDG-------ETFKAQRMVAFRTVELVQELIPSSPGLSFYFRINGKPIFLKGSNWIPVHAFQDQ 385

  Fly   390 QTNEQISHLLRSAKEAHMNMLRVWGGGVYESDYFYQLADSLGLLIWQDMMFACAMYPVNDEFLSS 454
            .|.:.|:.|||||::|:||.||||||||||.|:||.|.|..|::||||.|||||:||...:|:.:
Zfish   386 VTTDMITVLLRSAQKANMNALRVWGGGVYEQDFFYNLCDMYGIMIWQDFMFACALYPTERDFIQT 450

  Fly   455 VREEVRQNAMRLSHHPSVAIFVTNNENEAALVQNWYG-TLFERDRFESEYRELYLANVIHELKLV 518
            ||||:.|...||..||||.|:..|||||||:..:|:. ::.:|..:..:|..||:.| |.::.|.
Zfish   451 VREEITQQVRRLKSHPSVVIWSGNNENEAAIATDWFNISVADRPLYVKDYVNLYVDN-IRDIVLQ 514

  Fly   519 SHSSRPQPLVSSPSNGKASEPDNYISSNPQDNQNGDVHFYDYTKDGWDPGIFPRPRFVSEFGFQS 583
            ..|:||. |||||:||..||.:.:::.||.|...||.|:|:|..|.||...|||.||.||:||||
Zfish   515 EDSTRPF-LVSSPTNGVESEREGWVAQNPYDPNFGDTHYYNYFTDCWDWTAFPRTRFASEYGFQS 578

  Fly   584 FPGAYAWQR-SKGEDDDL-LGLITHRQHHPLGNVPVIALVERHLPLPFPEN--ENYATALIYFSQ 644
            :|......: |...|.|. .....|||||..||..::...|.|..||...:  :.|... ||.:|
Zfish   579 WPSLSTLSKVSVSSDWDFSSNFSAHRQHHEDGNQQMLRQAELHYILPNSTDSVQRYRDT-IYITQ 642

  Fly   645 IAQAMATKVETELYRSLR----DTPHRTMGALYWQLNDVWVAPSWSSIDFYGNWKLLHYWARDFL 705
            :.||...|::||.||..|    :....|||.|||||||:|..|||||::|.|.||:|||||.||.
Zfish   643 VMQAQCVKIQTEFYRRSRSDISEGKGHTMGTLYWQLNDIWQGPSWSSVEFGGKWKMLHYWAADFY 707

  Fly   706 APISIVALYEKSTDSLNISLICDQLEVDPRELNVVANVHL--WSQLLPRQSTSWDV-TLRPNGVQ 767
            ||:..|.:.:|.  .|.|..:.|:   ...:.:|.|.|.|  ||...|..|...:: |::..|..
Zfish   708 APVLSVGIEDKG--DLLIYAVSDR---QSEQHSVKAKVKLFSWSSFNPVCSLESNMTTVKAGGST 767

  Fly   768 YDKVIAISDLLQ--GEFTRTNAFLELQLRRGQDVIS-RTHFFPSSIAGAVGIEDPGLEFEIASRT 829
            .....::|.||.  |..||.:..:...|....:.|| ..|.|.||...|.|::.|.:.|.:
Zfish   768 LVFQQSMSALLSQCGNCTRRSCLITFHLSSAAEPISPHNHIFLSSPRQAEGLQKPNITFTV---- 828

  Fly   830 CLNTTNVVRNSVSISIQVKRPAVFVYLELLK-PYRYTLSENGFM 872
              ....||:| .::::....|||:|:|::.. |..:.|  |||:
Zfish   829 --KDAGVVQN-FAVTLHCSFPAVYVWLDVDDVPGHFNL--NGFL 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Man	NP_649436.2	LacZ	95..>710	CDD:442481	268/653 (41%)
		Mannosidase_ig	719..808	CDD:465505	24/94 (26%)
manba	NP_956453.1	LacZ	55..>711	CDD:442481	280/698 (40%)
		Mannosidase_ig	719..809	CDD:465505	23/94 (24%)
		Ig_mannosidase	821..899	CDD:465483	15/56 (27%)