Protein Alignment beta-Man and manba

DIOPT Version :10

• Sequence 1: NP_649436.2
• Gene: beta-Man / 40524
• FlyBaseID: FBgn0037215
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_002934804.3
• Gene: manba / 100485931
• XenbaseID: XB-GENE-985698
• Length: 885
• Species: Xenopus tropicalis
• Alignment Length: 902
• Identity: 312/902 - (34%)
• Similarity: 467/902 - (51%)
• Gaps: 120/902 - (13%)

  Fly    32 DKVEVIELS-NWTITNQNGSLTIANQTLPLGIYSAFAPQVL--DSY---NDVGLRYLAYDNFTFS 90
            |:.:...|: .|.|.|.:||..:..: :|..:::|.|.|:|  |.|   ||...:::|.|.:.:|
 Frog    27 DRSQTFSLNGRWDIRNSHGSYKLKGE-VPGCVHTALAEQLLIEDPYVRFNDAVYKWIAQDEWIYS 90

  Fly    91 NFFQ--FDVHHFNRGHINLTFHGIDTVSEIRLNHQLLGRTDNMFVRYSYEVSSLLQAENFLEVEI 153
            ..|.  .|:..:.:  :.|.|.||||||.|.||:..:.:|.|||.||:.:|:.::..:|.:||:.
 Frog    91 RTFSLPLDIRLWQK--VILVFEGIDTVSTILLNNISVAKTYNMFTRYTVDVTKIVAKDNNIEVQF 153

  Fly   154 QSPVVAALARANALKEAKKSVPPECPNERYHGECHMNMLRKMQASFSWDWGPAAPSAGIWKNVEL 218
            ||.|..|..|:.   .:...|||:||.:...||||:|.:||.|.||||||||:.|:.||||.|.:
 Frog   154 QSAVNWAKDRSG---NSTYKVPPDCPPQVQKGECHVNFIRKSQCSFSWDWGPSFPTQGIWKEVRI 215

  Fly   219 EIYE---------VAVIREVDVDVSRVNGSYWNMHIRCFLDAGGWQNFNGRL---VLYAVELLDR 271
            |.|.         |.|..::         |.|.:......|.    ..||.|   |...:..|:.
 Frog   216 EAYNAFHLDYLSFVPVFDKI---------SQWTVMFESVFDV----ITNGPLPGNVTVKIPDLNV 267

  Fly   272 PVVVDRYAIKNISHLAPVIEFDQAVPNGKVVTWWPNGYGEQKLYPLHFTLKTWLGPDGPEVRSKT 336
            ..:.....|.....|...::..:.:   :|..|||||||.|..|.|  |:| :|...|..|.:.|
 Frog   268 DEMQTFVLIPGQQELKMTVKISKKI---EVNLWWPNGYGSQNSYNL--TVK-FLFDGGYTVENTT 326

  Fly   337 KSHKSLRVGFRTLDLVEDPAPDGVGNTFLFRVNGVEMFMKGSNYIPSHLLPEMQTNEQISHLLRS 401
            |      :.||:::|||:|....:|.:|..::|.|.:|:||||:||:....:..|..::.:||:|
 Frog   327 K------IYFRSVELVEEPIQGSLGLSFYMKINQVPIFLKGSNWIPADSFQDKITLNRLHNLLQS 385

  Fly   402 AKEAHMNMLRVWGGGVYESDYFYQLADSLGLLIWQDMMFACAMYPVNDEFLSSVREEVRQNAMRL 466
            ..:|:||.|||||||:||||.||:|.|.||:::|||.|||||:||.:..||.:|..||.....||
 Frog   386 VVDANMNTLRVWGGGLYESDEFYRLCDELGIMVWQDFMFACALYPTDKWFLETVEAEVIHQMRRL 450

  Fly   467 SHHPSVAIFVTNNENEAALVQNWYGTLFER-DRFESEYRELYLANVIHELKLVSHSSRPQPLV-S 529
            ..|||:.::..|||||||:..||:....|: |.:..:|..||:..:   :.||......:|.: |
 Frog   451 RSHPSIIVWSGNNENEAAIADNWFSIPAEKEDVYRMDYVTLYIKTI---MPLVLKMDETRPFISS 512

  Fly   530 SPSNGKASEPDNYISSNPQDNQNGDVHFYDYTKDGWDPGIFPRPRFVSEFGFQSFPGAYA----- 589
            ||:|||.|..:.:::.||.||..||:|:|.|..|.||...:|:||..||:||||:|....
 Frog   513 SPTNGKESVQEYWLAKNPYDNHYGDIHYYSYITDCWDWKSYPKPRLASEYGFQSWPSLSTLKKVS 577

  Fly   590 ----WQRSKGEDDDLLGLITHRQHHPLGNVPVIALVERHLPLPFPENEN------YATALIYFSQ 644
                |..:.       ...:|||||..||..:::..:.|  ...|||.:      |.   :|.:|
 Frog   578 VPVDWHYTS-------NFCSHRQHHSSGNEQMLSQAKLH--YKNPENNDPIKEFQYT---LYLTQ 630

  Fly   645 IAQAMATKVETELY-RSLRDTP---HRTMGALYWQLNDVWVAPSWSSIDFYGNWKLLHYWARDFL 705
            :.||...|::||.| ||:|:..   ..|||||||||||:|.|||||||::.|.||:|||:|::|.
 Frog   631 VMQAQCVKLQTEFYRRSMREIVGGLGHTMGALYWQLNDIWQAPSWSSIEYGGKWKMLHYYAKNFF 695

  Fly   706 APISIVALYEKSTDSLNISLICD-------QLEVDPRELNVVANVHLWSQLLP-RQSTSWDVTLR 762
            .|::..|..:|  |.|.|..:.|       ||||         .|:.|:.||| .:..:.::...
 Frog   696 TPVAASAFEDK--DVLQIYGVSDLTKSLSLQLEV---------KVYRWNSLLPVCERLTEELIFN 749

  Fly   763 PNGVQYDKVIAISDLLQ--GEFTRTNAFLELQ-LRRGQDVISRTHFFPSSIAGAVGIEDPGLEFE 824
            .|..|..|. .|.:||:  ...||.|:.:... |.:||...|....:.:|:..|.|:..|.:...
 Frog   750 VNTSQIYKE-PIPELLRRCQNSTRENSVVVFSLLNQGQPYSSMNWHYLTSLKHAQGLLQPNITVS 813

  Fly   825 IASRTCLNTTNVVRNSVSISIQVKRPAVFVYLELLKPYRYTLSENGFMQTEPMHVVY 881
            |.........::|.:||         |.||:|::. ......|:|||:..|....||
 Frog   814 ITRENTGFAFHLVTSSV---------APFVWLDVW-DISGRFSDNGFLLAEKTKTVY 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Man	NP_649436.2	LacZ	95..>710	CDD:442481	245/647 (38%)
		Mannosidase_ig	719..808	CDD:465505	26/99 (26%)
manba	XP_002934804.3	LacZ	53..>701	CDD:442481	258/692 (37%)
		Mannosidase_ig	707..801	CDD:465505	27/103 (26%)
		Ig_mannosidase	807..883	CDD:465483	16/64 (25%)