Protein Alignment CG12581 and R148.5

DIOPT Version :9

• Sequence 1: NP_649435.2
• Gene: CG12581 / 40522
• FlyBaseID: FBgn0037213
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001370569.1
• Gene: R148.5 / 175422
• WormBaseID: WBGene00020104
• Length: 528
• Species: Caenorhabditis elegans
• Alignment Length: 680
• Identity: 187/680 - (27%)
• Similarity: 254/680 - (37%)
• Gaps: 252/680 - (37%)

  Fly     6 PICRCRVLYLGSAVPRQSKDGLQGIQEPLRSLYPSEGAVGAKGIDSWLSVWSNGILLENVDENLK 70
            |:|||||||:||:||..:||||||||:||:..||.:.:...:||||||||||||:|||.::...|
 Worm     4 PLCRCRVLYIGSSVPTITKDGLQGIQQPLKERYPIQESPDTRGIDSWLSVWSNGVLLEYIEGEKK 68

  Fly    71 QITRFFPIESLHYCAAVRQVLIPERGNTHPEPKFLPLDSPFARMPRAQHPPIFAAILRRTTGIKV 135
            ..|.||||.:||||||||.|.:..........:|:|||||||.:|.:.||||||||.|||||:||
 Worm    69 TETVFFPIITLHYCAAVRYVNVEGFKVGGGGEQFMPLDSPFANIPNSPHPPIFAAIFRRTTGVKV 133

  Fly   136 LECHVFICKREAAANALVRCCFHAYADNSYARQLETGGGSSVYGTLKSGAISKSSSDLTGVGLAN 200
            ||||.|||....||||||||..|||.:..:.|..|.
 Worm   134 LECHGFICTNVKAANALVRCMVHAYTETMHLRMDER----------------------------- 169

  Fly   201 GVGNGSGGGNHHLSLSAQGGWRSRTGSTTTLNSLGRASNGHANGSAIGMNGSSAVSAAEGYTSVK 265
                                                            :.|..|:.  ||.|..:
 Worm   170 ------------------------------------------------IPGLKAIK--EGSTGDR 184

  Fly   266 NFYGSSADLNVAVDDGDASFNGD-----ENHKVWNGSQDQLDSIGPLESPYELFAGNTSTLGRPL 325
            :....|:::.      :.||..|     :|.|.|...:.|       :..|:..:.::|.:
 Worm   185 SPNSPSSEIE------ENSFEEDVVPEEKNMKNWQERRQQ-------DGEYDSVSISSSLV---- 232

  Fly   326 RARQISTPIDVPPPPVKDERKTKRDKKLTKSSGSQSLSGTLIRPKPVHPAPQHRSGFQGPSGPGS 390
                                  .::||.....|  .:.|.|:    ....|..|:|..
 Worm   233 ----------------------NKNKKAASEQG--GIRGALV----PFDEPLRRAGSD------- 262

  Fly   391 VTYGHVSGHGLHAARYHTISHRGIPPGSHSHLTHHP--PPHPSQNQVHMMHHPHI---------- 443
                            :.:|:||.||       |||  ||||       ||||:.
 Worm   263 ----------------NDLSYRGPPP-------HHPYGPPHP-------MHHPYAMMPPPFGFFP 297

  Fly   444 ----GGLPP---------MQIPVMMPQQYATLQPSRSTGKKKKKDKKSGAGGGVPVGMPIVP--- 492
                |..||         |..|.|.|..:..:.|.|  |...........||..|...|..|
 Worm   298 PPPRGHFPPPPPHFMGRGMPPPFMPPPPHFGMGPPR--GFMPPPHPMMFRGGPYPPFFPPPPPHF 360

  Fly   493 -----------PIYAFQQQVVGV--------PAPQLAQSLIGETRPLGHSSRKLAASMGNG---- 534
                       ||....:.|.|.        ||      .:|.|.....:|.:.|...|:|
 Worm   361 MRPSSPPTDGGPIITGPESVYGTMRRGAYEEPA------YVGATGGFPEASYQPANYGGDGYETY 419

  Fly   535 LDDSGNSG----AESPSPGGT-----------GIYKRKGHLNERAFSYSIRQEHRSRSHGSLASL 584
            .|.....|    .||.|...|           ||| ||.|:||:|||.::|         |:|:.
 Worm   420 YDTFKKRGTLKKGESASMASTRADSAWDQYEAGIY-RKPHINEKAFSGTLR---------SMAAK 474

  Fly   585 QFNPPDIKKER--EIAQMVAGLDLNEGERP 612
            :.:...:.:..  |:|......::...:.|
 Worm   475 ETSNATLNRSEHAEVASQTVETEITRPDSP 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12581	NP_649435.2	PTB_CG12581	3..168	CDD:241252	96/161 (60%)
R148.5	NP_001370569.1	PTB_CG12581	1..166	CDD:241252	96/161 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158542
Domainoid	1	1.000	234	1.000	Domainoid score	I1339
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I2153
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0014417
OrthoInspector	1	1.000	-	-		oto18242
orthoMCL	1	0.900	-	-		OOG6_114634
Panther	1	1.100	-	-	LDO	PTHR21219
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17050
SonicParanoid	1	1.000	-	-		X11820
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.010