Protein Alignment nAChRalpha4 and HTR3B

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_006019.1
• Gene: HTR3B / 9177
• HGNCID: 5298
• Length: 441
• Species: Homo sapiens
• Alignment Length: 325
• Identity: 85/325 - (26%)
• Similarity: 146/325 - (44%)
• Gaps: 47/325 - (14%)

  Fly     9 NPDAKRLY---DDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70
            :|....||   ..||..|:|.||||.|.|....|.:.|.:..::||:.:|||:.|::|.::.|.|
Human    26 HPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWND 90

  Fly    71 YKLRWEPKEYGGVHMLHVPSDHIWRPDIVL---------------YNNADGNFEVTLATKATIYS 120
            ..|.|....:..:..:.:|...||.|||::               |.|:.|..|
Human    91 EFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIE----------- 144

  Fly   121 EGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLS 185
                .:||..:. |:|.::...||||.|.|.|.|.|..:....|||..:...:.     :..|..
Human   145 ----NYKPIQVV-SACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPED-----IQHDKK 199

  Fly   186 EFYMSVEWDILEVPAVRNEKFYTCCDEP---YLDITFNITMRRKTLFYTVNIIIPCMGISFLTVL 247
            .|....||::|.|.:.     |:.....   :..|.||:.|||..|.|.|:::||.:.:..:.:.
Human   200 AFLNDSEWELLSVSST-----YSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLG 259

  Fly   248 TFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVL 312
            :||||.:...::....|:|:...||.:.:...:|.:....||:|.:....|..:.:|:..::|::
Human   260 SFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLV 324

  Fly   313  312
            Human   325  324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	85/325 (26%)
		Neur_chan_LBD	12..227	CDD:280998	64/235 (27%)
		Neur_chan_memb	234..505	CDD:280999	17/79 (22%)
HTR3B	NP_006019.1	LIC	8..435	CDD:273305	85/325 (26%)
		Neur_chan_LBD	33..239	CDD:280998	63/231 (27%)
		Neur_chan_memb	246..>328	CDD:280999	17/79 (22%)
		HA-stretch	381..413

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810