Protein Alignment nAChRalpha4 and CHRFAM7A

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_647536.1
• Gene: CHRFAM7A / 89832
• HGNCID: 15781
• Length: 412
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 163/440 - (37%)
• Similarity: 236/440 - (53%)
• Gaps: 48/440 - (10%)

  Fly    92 HIW---RPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLK 153
            |:|   ..||     ||..|:.|..|...:.|.|..::.||.|:||||.|||.:||||.|.|.||
Human    18 HLWIAANCDI-----ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLK 77

  Fly   154 FGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDIT 218
            ||||:|.|:.:||: |.|          .|:|.:..:.|||::.:|..|:|:||.||.|||.|:|
Human    78 FGSWSYGGWSLDLQ-MQE----------ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVT 131

  Fly   219 FNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPT 283
            |.:||||:||:|.:|::|||:.||.|.:|.|.||:|||||::|.|::|:||.||.|||.||:|.|
Human   132 FTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPAT 196

  Fly   284 SLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYN 348
            |..|||:.:|....||:|.:|:.|||:||..|...|...||..|.:.:.:::...||.:|||..:
Human   197 SDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGED 261

  Fly   349 FETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLT 413
                    |...||.:.....:    |.|...:...|....:.::...| |.|...||....|.:
Human   262 --------KVRPACQHKQRRCS----LASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDS 313

  Fly   414 HCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKED 478
            ......:|..|..|...|....|...:|.      |.||.:.   ||:||...:.|::|..|..:
Human   314 GVVCGRMACSPTHDEHLLHGGQPPEGDPD------LAKILEE---VRYIANRFRCQDESEAVCSE 369

  Fly   479 WKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDFS 528
            ||:.|.|:|||.|..|::..::.|.||::.||.       .:|....||:
Human   370 WKFAACVVDRLCLMAFSVFTIICTIGILMSAPN-------FVEAVSKDFA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	156/415 (38%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	62/139 (45%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
CHRFAM7A	NP_647536.1	LIC	<28..400	CDD:455710	154/404 (38%)