DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha4 and CHRNA6

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_004189.1	Gene:	CHRNA6 / 8973	HGNCID:	15963	Length:	494	Species:	Homo sapiens

Alignment Length:	503	Identity:	219/503 - (43%)
Similarity:	312/503 - (62%)	Gaps:	59/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            :||:..|.|:||:.:|||.|.:|.:.|..::.::||.:|:..||||.||||:...|.||||||:|
Human    35 ERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDP 99

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEY 142
            .||.|:..|.||:|.||:|||||||||.|:|:|...|||.:...|::.|.||||:||||.:|:.:
Human   100 MEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITF 164

  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFY 207
            ||||.|.|.|||||||||..::||.         ::...||:::|:.:.||:|::....:::..|
Human   165 FPFDHQNCSLKFGSWTYDKAEIDLL---------IIGSKVDMNDFWENSEWEIIDASGYKHDIKY 220

  Fly   208 TCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVF 272
            .||:|.|.|||::..:||..:|||:|:||||:.|||||||.||||||.||||||.||:|:||.||
Human   221 NCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVF 285

  Fly   273 FLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLP 337
            .|::.|.||.|||||||:|:||:|.||.|::||.|||.|||:|:|:|.||.|..|||.||:..||
Human   286 LLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLP 350

  Fly   338 AFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGS 402
            ..|.::.|                          :|:...:| ::::|:.      .|..|..|.
Human   351 QVLLMRWP--------------------------LDKTRGTG-SDAVPRG------LARRPAKGK 382

  Fly   403 CQVHGPVPPLTHC----SSDEIAAVPDMDIGPLGMKSPILNNP---AFSHSKCLPKIHKSCFCVR 460
            ...||....|..|    .|:|:|.          .|..:.:.|   ...:|:..|::......|:
Human   383 LASHGEPRHLKECFHCHKSNELAT----------SKRRLSHQPLQWVVENSEHSPEVEDVINSVQ 437

  Fly   461 FIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQ 508
            ||||:.|...::.:|::||||||||:||:|||:|.:..|.||||:.||
Human   438 FIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQ 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	216/498 (43%)
		Neur_chan_LBD	12..227	CDD:280998	99/213 (46%)
		Neur_chan_memb	234..505	CDD:280999	113/277 (41%)
CHRNA6	NP_004189.1	Neur_chan_LBD	34..484	CDD:332142	217/500 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1448
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910