Protein Alignment nAChRalpha4 and LOC798522

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_001338964.6
• Gene: LOC798522 / 798522
• -ID: -
• Length: 488
• Species: Danio rerio
• Alignment Length: 504
• Identity: 179/504 - (35%)
• Similarity: 284/504 - (56%)
• Gaps: 46/504 - (9%)

  Fly    12 AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76
            |.:|.:||:.:|:..:|||.:|...|.|.:::.|||:.|::.:||::...||:.|.|:|..|:|.
Zfish    30 AHKLLNDLMEDYSSALRPVDDTDKSLNVTLQVTLSQIKDMDERNQVLIAYLWIRQVWHDAHLKWS 94

  Fly    77 PKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVE 141
            .::|.|:.::.:||..|||||:||||.||.:|...:.|...:...|.:.|..|||.||||.:||.
Zfish    95 KEDYDGLEVIRIPSSLIWRPDLVLYNKADDDFSGPVDTNVVLRYTGEITWDAPAITKSSCVVDVS 159

  Fly   142 YFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKF 206
            |||||.|.|.|.||||||:|.:||:     ..||    |..|||:|..:|||:...:||.:|...
Zfish   160 YFPFDSQQCNLTFGSWTYNGNQVDI-----AMGS----VSGDLSDFVENVEWECHGMPATKNVIM 215

  Fly   207 YTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHV 271
            |.||.:||.|||:.:.::|::.||.:|:::||..||||..|:||||:||||||:|.:::|::|.|
Zfish   216 YGCCSDPYPDITYTVLLQRRSSFYIINLLLPCFLISFLAPLSFYLPADSGEKVSLGVTVLLALTV 280

  Fly   272 FFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFL 336
            |.::|.|.:|| |..|||:.||.|..|.:::.|..:|:.::|:||...:...:..|.|.:.||::
Zfish   281 FQMMVAESMPP-SESVPLIAKYYIATMTMITASTALTIFIMNIHFCGAEAKPVPYWAKVLIIDYM 344

  Fly   337 PAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGG 401
            ....|:      :|..:       :|..|:..|...:...|..::.   |..|      :.|.|
Zfish   345 SKIFFV------YEVGE-------SCASPFGQAEESESFHSQNHHR---KHKL------HHPKG- 386

  Fly   402 SCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHT 466
              ::.|..||.  |..|..:..      .||.:|.:.......:..|..|:.::   |.:||...
Zfish   387 --KISGSPPPC--CPEDHKSPF------VLGCESCVYCGFRSGNLACDTKLLRN---VEYIANCF 438

  Fly   467 KMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDD 515
            :.|:.:.....:||.||.|:||.|:|||.:.|.:.:..||.:|||..:|
Zfish   439 REQKTTALKVAEWKKVAKVMDRFFMWIFFIMVFLMSILIIGKAPTTNND 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	173/492 (35%)
		Neur_chan_LBD	12..227	CDD:280998	91/214 (43%)
		Neur_chan_memb	234..505	CDD:280999	79/270 (29%)
LOC798522	XP_001338964.6	Neur_chan_LBD	32..477	CDD:332142	172/490 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910