Protein Alignment nAChRalpha4 and chrnb3a

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_957514.1
• Gene: chrnb3a / 794401
• ZFINID: ZDB-GENE-040108-1
• Length: 467
• Species: Danio rerio
• Alignment Length: 501
• Identity: 209/501 - (41%)
• Similarity: 285/501 - (56%)
• Gaps: 78/501 - (15%)

  Fly    17 DDLLSN----YNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            |.||.|    |.|.||||::..|.:.|...||:|||:||:.|||:||||:|:.:.|.||||||.|
Zfish    33 DTLLRNLFRGYQKWVRPVLHANDTITVRFGLKISQLVDVDEKNQLMTTNVWLWEEWTDYKLRWNP 97

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEY 142
            ::|||:..:.|||:.||.||||||.||||.||.:|.|||.:...|.:.|.|||.|||:|.:||.:
Zfish    98 EDYGGITSIRVPSETIWLPDIVLYENADGRFEGSLMTKAIVRFNGTIMWTPPASYKSACTMDVTF 162

  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFY 207
            ||||.|.|.:|||||||||..|||..:|..         ||..:|:.:.||:||.....|..:..
Zfish   163 FPFDRQNCSMKFGSWTYDGTMVDLTLVDAY---------VDRKDFFDNGEWEILNATGQRGSRRD 218

  Fly   208 TCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVF 272
            .....|||  |::..::|..||||:.:||||:|:||||||.||||||.|||::||.|:|:||.||
Zfish   219 GIYSYPYL--TYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVF 281

  Fly   273 FLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQT-HKMAPWVKRVFIDFL 336
            .|::.||||.:|.|:||:|:||:|.||.|:.||.|||.|:|||.||..| |.||||||.:|:..|
Zfish   282 LLVIEEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSATYHPMAPWVKSLFLQRL 346

  Fly   337 PAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGG 401
            |..|.::..|..::...:.|:           :..:.|.:..|...|.               ||
Zfish   347 PRLLCMRGHTDRYQYPDIELR-----------SPELKRGMKKGQQKSA---------------GG 385

  Fly   402 SCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHT 466
                                       |..|:|..  .|.|:     :..:.|:...|.:|:.|.
Zfish   386 ---------------------------GRAGVKED--ENQAW-----IALLEKATHSVHYISRHI 416

  Fly   467 KMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTL 512
            :.:....:|.:|||:||.||||:|||.|....|:||  |::..|.|
Zfish   417 RKEHFIREVVQDWKFVAQVLDRIFLWAFLTVSVLGT--ILIFTPAL 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	206/492 (42%)
		Neur_chan_LBD	12..227	CDD:280998	102/213 (48%)
		Neur_chan_memb	234..505	CDD:280999	100/271 (37%)
chrnb3a	NP_957514.1	LIC	9..459	CDD:273305	207/498 (42%)
		Neur_chan_LBD	32..236	CDD:280998	102/213 (48%)
		Neur_chan_memb	243..456	CDD:280999	101/274 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830