Protein Alignment nAChRalpha4 and Htr3a

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_006243083.1
• Gene: Htr3a / 79246
• RGDID: 61818
• Length: 488
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 133/506 - (26%)
• Similarity: 232/506 - (45%)
• Gaps: 86/506 - (16%)

  Fly    10 PDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLR 74
            |...||.|.||:||.|.||||.:......|.|.:.:..:::|:.|||::||.:|..|.|.|..|:
  Rat    37 PALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQ 101

  Fly    75 WEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEID 139
            |.|:::..|..|.:|:|.||.|||::....|.....:: ....::.:|.|:...|....::|.:|
  Rat   102 WTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSI-PYVYVHHQGEVQNYKPLQLVTACSLD 165

  Fly   140 VEYFPFDEQTCVLKFGSW--TYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVR 202
            :..||||.|.|.|.|.||  |.....:.|....|:       |..|.|.|....||::|.| ..:
  Rat   166 IYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEE-------VRSDKSIFINQGEWELLGV-FTK 222

  Fly   203 NEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILI 267
            .::|.......|.::.|.:.:||:.|||.|::::|.:.:..:.::.|.||.||||:|:..|::|:
  Rat   223 FQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLL 287

  Fly   268 SLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVF 332
            ...||.::|.:.:|.|::..||:|.|.:..|.|:.||:..|:.::.:..:......:..|::.:.
  Rat   288 GYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLV 352

  Fly   333 IDFLPAFLFI------KRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQ 391
            :|.:...|.:      .||...|:.:|                                .:|.|.
  Rat   353 LDRIAWLLCLGEQPMAHRPPATFQANK--------------------------------TDDCSG 385

  Fly   392 SITANGPFGGSCQVHGPVPPL-THCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKS 455
            |:               :|.: .|||  .:.:..|::.......||            ||...::
  Rat   386 SL---------------LPAMGNHCS--HVGSPQDLEKTSRSRDSP------------LPPPREA 421

  Fly   456 CFCVRFIAE------HT-KMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVV 499
            ...||.:.:      |: :.:::..:|..||..|..|||||...|:.|||:
  Rat   422 SLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVL 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	133/506 (26%)
		Neur_chan_LBD	12..227	CDD:280998	68/216 (31%)
		Neur_chan_memb	234..505	CDD:280999	60/280 (21%)
Htr3a	XP_006243083.1	LIC	5..482	CDD:273305	133/506 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810