DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha4 and chrna2a

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001035417.1	Gene:	chrna2a / 678575	ZFINID:	ZDB-GENE-040108-2	Length:	520	Species:	Danio rerio

Alignment Length:	502	Identity:	236/502 - (47%)
Similarity:	315/502 - (62%)	Gaps:	36/502 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            :|:..|...|||..|||.|.:||:.|...|.::|||||:.|||:||||:|::|.|.||||||.|.
Zfish    39 KLFHKLFIGYNKWSRPVRNISDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNPS 103

  Fly    79 EYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYF 143
            |:..|..:.|||:.||.|||||||||||.|.||..|||.::..|.|.|.|||||||||.|||.:|
Zfish   104 EFDNVTSIRVPSEMIWVPDIVLYNNADGEFAVTHMTKAHLFHTGKVSWVPPAIYKSSCSIDVTFF 168

  Fly   144 PFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYT 208
            |||:|.|.:||||||||..|:||   ::.:|:      |||.:::.|.||.|:......|.|.|.
Zfish   169 PFDQQNCKMKFGSWTYDKAKIDL---EQIEGT------VDLKDYWESGEWAIINAVGTYNTKKYD 224

  Fly   209 CCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFF 273
            ||.|.|.|||:...:||..||||:|:||||:.||.||||.||||||.|||:||.||:|:||.||.
Zfish   225 CCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFL 289

  Fly   274 LLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPA 338
            ||:.||||.||||:||:|:||:|.||.|::||.:||.|||||.|||.||.|..||..||:|.:|.
Zfish   290 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHSMPRWVHSVFLDHIPR 354

  Fly   339 FLFIKRP--------TYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITA 395
            :||::||        |.|..|||..          :...|.:|.||.......:   .||.||::
Zfish   355 WLFMRRPEPEKKPKKTANLSTSKSW----------FQQETGVDGLVCQDMEFGI---GLSTSISS 406

  Fly   396 NGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVR 460
              |...|..:....|.|.......:..|.::...|..:.: :::.|....|.|:.:..:.   ||
Zfish   407 --PSATSLHLSDSEPLLQKYELQHLGHVVNLCQHPAKLGN-LVSEPGLLFSPCVLRALEG---VR 465

  Fly   461 FIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIIL 507
            :||:|.:.:::...|||||||||||:||:|||:|.:..::||.|:.|
Zfish   466 YIADHLRAEDEDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGLFL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	234/498 (47%)
		Neur_chan_LBD	12..227	CDD:280998	111/212 (52%)
		Neur_chan_memb	234..505	CDD:280999	118/278 (42%)
chrna2a	NP_001035417.1	LIC	9..513	CDD:273305	236/502 (47%)
		Neur_chan_LBD	37..243	CDD:280998	111/212 (52%)
		Neur_chan_memb	250..511	CDD:280999	119/279 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.810