Protein Alignment nAChRalpha4 and Chrna9

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_075219.2
• Gene: Chrna9 / 65024
• RGDID: 621534
• Length: 479
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 192/506 - (37%)
• Similarity: 279/506 - (55%)
• Gaps: 66/506 - (13%)

  Fly    12 AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76
            |::|:.||..:|:..:|||.:|..||.|.:::.|||:.|::.:|||:|..||:.|:|:|..|.|:
  Rat    31 AQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWD 95

  Fly    77 PKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVE 141
            ..:|..:..:.:|||.:|||||||||.||......:.|...:..:||:.|..|||.||||.:||.
  Rat    96 RDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVT 160

  Fly   142 YFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKF 206
            |||||.|.|.|.||||||:|.:||:        .|.:..| |||:|...|||::..:|||:|...
  Rat   161 YFPFDSQQCNLTFGSWTYNGNQVDI--------FNALDSG-DLSDFIEDVEWEVHGMPAVKNVIS 216

  Fly   207 YTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHV 271
            |.||.|||.|:||.:.::|::.||.||::|||:.||||..|:||||:.|||||:|.::||:::.|
  Rat   217 YGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTV 281

  Fly   272 FFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFL 336
            |.|:|.||: |.|..|||:|||.|..|.|::.|..:|::|:|:||...:...:..|.|.|.:.::
  Rat   282 FQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYM 345

  Fly   337 PAFLFIKRPTYNFETSKLLLKDTHACFYPYYS-----ATNI-DRLVSSGYNNSLPKEDLSQSITA 395
            ...||:    |:...|         |..|.:|     .|.: .:|..|....|..| |||:....
  Rat   346 SRILFV----YDVGES---------CLSPRHSQEPEQVTKVYSKLPESNLKTSRNK-DLSRKKEV 396

  Fly   396 NGPFGGSCQVHGPVPPLT--HCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFC 458
            ...........|.:|..|  :|:..|                .:..|..:. :||| |.||
  Rat   397 RKLLKNDLGYQGGIPQNTDSYCARYE----------------ALTKNIEYI-AKCL-KDHK---- 439

  Fly   459 VRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQA 509
                |.::|..|        ||.||.|:||.|:|||...|.|.|..||.:|
  Rat   440 ----ATNSKGSE--------WKKVAKVIDRFFMWIFFAMVFVMTVLIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	189/500 (38%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	95/216 (44%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
Chrna9	NP_075219.2	LIC	8..474	CDD:455710	189/500 (38%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	95/214 (44%)
		Cys-loop	155..169	CDD:349823	9/13 (69%)