DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha4 and Htr3b

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_071525.1	Gene:	Htr3b / 58963	RGDID:	61820	Length:	437	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	81/319 - (25%)
Similarity:	150/319 - (47%)	Gaps:	8/319 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYK 72
            ||....||...||..|:|.||||.|..:...|.:.|.:..::||:::||.:.|::|..:.|.|..
  Rat    24 GNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEF 88

  Fly    73 LRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCE 137
            |.|....:..:..:.:|...||.|||::....|......| ....:.|.|.:....|....|:|.
  Rat    89 LSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDL-PYVYVNSSGTIRNHKPIQVVSACS 152

  Fly   138 IDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVR 202
            :....||||.|.|.|.|.|..:....:||..:..|:.     :..|...|....||.:|.|.:..
  Rat   153 LQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNQED-----IENDKRSFLNDSEWQLLSVTSTY 212

  Fly   203 NEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILI 267
            :.:..:..|  :..|.||:.:||..|.|.|:::||.:.:..:.:.:||||.:...::....::|:
  Rat   213 HIRQSSAGD--FAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLV 275

  Fly   268 SLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAP 326
            ...||.:.:.:.:|.::....|:|.:....|.|:.:|:..:::::...:....:.:..|
  Rat   276 GYTVFRVNMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSEQERP 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	81/319 (25%)
		Neur_chan_LBD	12..227	CDD:280998	60/214 (28%)
		Neur_chan_memb	234..505	CDD:280999	16/93 (17%)
Htr3b	NP_071525.1	LIC	30..431	CDD:273305	79/313 (25%)
		Neur_chan_LBD	30..233	CDD:280998	58/210 (28%)
		Neur_chan_memb	242..>313	CDD:280999	14/70 (20%)
		HA-stretch	377..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900