Protein Alignment nAChRalpha4 and htr3a

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_073791438.1
• Gene: htr3a / 571641
• ZFINID: ZDB-GENE-071012-5
• Length: 494
• Species: Danio rerio
• Alignment Length: 506
• Identity: 135/506 - (26%)
• Similarity: 239/506 - (47%)
• Gaps: 63/506 - (12%)

  Fly     9 NPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 73
            |....||.:.|.:.|.|.||||.:......|.|.|.:..:::|:.|||::||.:|..|.|.|..|
Zfish    35 NATLVRLNEFLSAGYKKGVRPVRDWRQSTTVAIDLMVYAILNVDEKNQVLTTYVWYRQQWTDEFL 99

  Fly    74 RWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIY--SEGLVEWKPPAIYKSSC 136
            .|:|:|:..|..:.:|:.:||.|||::....|......:   ..:|  .:|||....|....::|
Zfish   100 MWDPEEFDEVKKISIPTANIWIPDILINEFVDVGKSPDI---PYVYVGHDGLVSNYKPIQVVTAC 161

  Fly   137 EIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAV 201
            .:::..||:|.|.|.|.|.||.:....:::..|...:     ||..|.|.|....||::|.|.:.
Zfish   162 SLNIYNFPYDVQKCSLTFQSWLHTTKDINITLMRSPE-----AVKTDKSVFMNQGEWELLHVLST 221

  Fly   202 RNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISIL 266
            .| .|....|:.|.::.|::.:||:.||||||:::|.|.:..:.::.||||.||||:|:..|::|
Zfish   222 YN-AFSIDNDDYYAEMKFHVVIRRRPLFYTVNLLLPSMFLMVMDIVGFYLPPDSGERVSFKITLL 285

  Fly   267 ISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRV 331
            :...||.::|.:.:|.|::..||:|.|.:..|.|:.||:..:|:::.:..:.....::..|||.:
Zfish   286 LGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLTESVLIVRLVHKQDLQSRVPQWVKHL 350

  Fly   332 FIDFLPAFLFIKRP---TYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSI 393
            .::.....|.|:..   ::..:.|.|          |.|...|:         |:..::|....|
Zfish   351 VLEKATVLLCIRNKKICSFRSQGSDL----------PLYKENNM---------NTAEQQDTLTMI 396

  Fly   394 TANGPFGGSCQVHGPVPPLTHCSSDEIAAVPD--MDIGPLGMKSPILNNPAFSHSKCLPKIHKSC 456
            |:                ..||:........|  ..:| ||:.         :|....|.:....
Zfish   397 TS----------------AIHCNHHSCEGSRDSGRTLG-LGLS---------AHESGPPVMDGIL 435

  Fly   457 FCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIIL 507
            ..:..|.:..:.:::|.::.::|..|..|||.|...::.|.|:  ..||.|
Zfish   436 REITTIRQFLEKKDESREIAKEWLQVGYVLDILLFRVYLLTVL--AYGITL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	132/502 (26%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	66/219 (30%)
		Cys-loop	136..150	CDD:349832	5/13 (38%)
htr3a	XP_073791438.1	None