Protein Alignment nAChRalpha4 and htr3b

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_021324909.1
• Gene: htr3b / 571632
• ZFINID: ZDB-GENE-071012-4
• Length: 369
• Species: Danio rerio
• Alignment Length: 380
• Identity: 106/380 - (27%)
• Similarity: 184/380 - (48%)
• Gaps: 54/380 - (14%)

  Fly    19 LLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKEYGGV 83
            ||..||..||||.|.|....:.|.|.:..::||:.:.|.:||::|..|.|.|..|.|:|.|:.|:
Zfish    36 LLRKYNCGVRPVQNWTKPTTIYIDLIIQAVLDVDGQTQKVTTSIWYRQIWNDEFLVWDPDEFDGI 100

  Fly    84 HMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQ 148
            ..:.:.||.||.||:::....|......:.......|..:..:||..:. |:|.:::..||||:|
Zfish   101 TEISLSSDAIWVPDLIISEFVDVGKSPVIPYVYVNCSGKVKNYKPIQVV-SACHLEIYAFPFDKQ 164

  Fly   149 TCVLKFGSWTYDGFKVDL---RHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCC 210
            .|.|.|.||.:...:|||   |..:|        :..|..||....||::|.||:    :::|..
Zfish   165 NCTLTFRSWLHSVSEVDLALWRPAEE--------IANDTREFMNDGEWELLGVPS----RYWTLN 217

  Fly   211 --DEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFF 273
              |..|..|.||:.:||:.|.|.|.::||.:.:..:.|::||||.:||.::|...|||:...|..
Zfish   218 LEDRDYAQIQFNVLIRRRPLLYVVGLLIPSIFLMVVDVISFYLPPNSGTRITFKTSILLGYTVIR 282

  Fly   274 LLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLN-VHFRSPQTHKMAPWVKRVFIDFLP 337
            :.:::.||.|::..||:|.:....|.|:.:|:.:::.|:. :|:...:..:|:
Zfish   283 VNLMDEIPATAIKTPLIGVFFAICMALLLLSLAMSIFVVKLLHYSEKEVKEMS------------ 335

  Fly   338 AFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQS 392
                                 ..||....|.  ::|:.:.|.:.:....:|:.||
Zfish   336 ---------------------MSACLLDKYG--SMDQSLESTFTSMKTLDDVDQS 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	106/380 (28%)
		Neur_chan_LBD	12..227	CDD:280998	69/212 (33%)
		Neur_chan_memb	234..505	CDD:280999	34/160 (21%)
htr3b	XP_021324909.1	Neur_chan_LBD	26..>325	CDD:332142	96/301 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910