DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha4 and CHRNA10

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_065135.2 Gene:CHRNA10 / 57053 HGNCID:13800 Length:450 Species:Homo sapiens


Alignment Length:498 Identity:170/498 - (34%)
Similarity:257/498 - (51%) Gaps:78/498 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76
            |.:|:.||.:||...:|||.:|...|.|.:::.|||:||::.:||::|..||:.|.|.|..|||:
Human    30 ALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWD 94

  Fly    77 PKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVE 141
            |..|||:..:.:||..:|||||||||.||.....:.:|...:..:|.|.|..|||.:|||.:||.
Human    95 PNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVA 159

  Fly   142 YFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKF 206
            .||||.|.|.|.|||||:.|.::|:|    .:|:     ...|::|..:|||.:|.:||.|....
Human   160 AFPFDAQHCGLTFGSWTHGGHQLDVR----PRGA-----AASLADFVENVEWRVLGMPARRRVLT 215

  Fly   207 YTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHV 271
            |.||.|||.|:||.:.:||:...|..|:::||:.||.|..|.|:||:||||||:|.:::|::|.|
Human   216 YGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTV 280

  Fly   272 FFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFL 336
            |.||:.|.:||.. .|||:|||.:..|.:|:.|..:|::::|:|:..|....:..|.:.:.:..|
Human   281 FQLLLAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHL 344

  Fly   337 PAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGG 401
            ...|.::             :....|                  ..|.|.| ||.|  ...|.||
Human   345 ARGLCVR-------------ERGEPC------------------GQSRPPE-LSPS--PQSPEGG 375

  Fly   402 SCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHT 466
            :      .||...|                       :.|     :||.:.......|..||...
Human   376 A------GPPAGPC-----------------------HEP-----RCLCRQEALLHHVATIANTF 406

  Fly   467 KMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQA 509
            :....:.:..||||.:|.|:||.||.||....:|.:..:::||
Human   407 RSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 168/492 (34%)
Neur_chan_LBD 12..227 CDD:280998 93/214 (43%)
Neur_chan_memb 234..505 CDD:280999 73/270 (27%)
CHRNA10NP_065135.2 LIC 31..442 CDD:273305 167/488 (34%)
Neur_chan_LBD 32..235 CDD:280998 91/211 (43%)
Neur_chan_memb 243..434 CDD:280999 70/259 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..380 11/51 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.