Protein Alignment nAChRalpha4 and chrnb5b

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_017214550.1
• Gene: chrnb5b / 569662
• ZFINID: ZDB-GENE-120809-5
• Length: 475
• Species: Danio rerio
• Alignment Length: 473
• Identity: 202/473 - (42%)
• Similarity: 279/473 - (58%)
• Gaps: 68/473 - (14%)

  Fly    13 KRLYDDLLS--NYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRW 75
            :||.:.|||  .||||:||.||.:..:.:.|::.|:|||.||.:.||||||.|:.|.|.||:|.|
Zfish    26 ERLVNYLLSPDRYNKLIRPAVNKSQQVTIAIQVSLAQLISVNEREQIMTTNCWLTQVWNDYRLMW 90

  Fly    76 EPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDV 140
            :|:||.|:..:.:||.|||.|||||||||||.:||:..:.|.:.:.|.|.|.|||||||:|:|:|
Zfish    91 DPEEYEGMRKVRLPSQHIWLPDIVLYNNADGTYEVSFYSNAVVSNNGEVAWLPPAIYKSACKIEV 155

  Fly   141 EYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEK 205
            ..||||:|.|.|||.|||||..::||..:.:....:         :|..|.||||:.:|..:||
Zfish   156 RDFPFDQQNCTLKFRSWTYDHTEIDLILLSDFASRD---------DFKPSGEWDIVSLPGRKNE- 210

  Fly   206 FYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLH 270
              ...|..|||||::..:|||.||||:|:||||:.|:.|.:|.||||||.|||:||.||:|::|.
Zfish   211 --DPNDVTYLDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKITLCISVLLALT 273

  Fly   271 VFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDF 335
            ||.||:.:|:|||||.|||:||||:|.|:||:.||..:|.|||||.|||.||.|..|||..|:..
Zfish   274 VFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHSMPKWVKYYFLVR 338

  Fly   336 LPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNI------DRLVSSGYNNSLPKEDLSQSIT 394
            ||||||::||.   |::|   :|.....:..:|::::      |...|:.:.|    ||.:..|
Zfish   339 LPAFLFMRRPG---ESNK---RDRFRRKHQQHSSSDVPVKSEADEADSTFFVN----EDSANHI- 392

  Fly   395 ANGPFGGSCQVHGPVPP--LTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCF 457
              |...|..|.:..:..  ...||:|...||..
Zfish   393 --GWRAGELQENSELRKRMAVKCSADMEEAVKG-------------------------------- 423

  Fly   458 CVRFIAEHTKMQEDSTKV 475
             ||:||:..|.::|...|
Zfish   424 -VRYIADKMKSEDDDEGV 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	202/473 (43%)
		Neur_chan_LBD	12..227	CDD:280998	102/215 (47%)
		Neur_chan_memb	234..505	CDD:280999	94/250 (38%)
chrnb5b	XP_017214550.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920