Protein Alignment nAChRalpha4 and chrna11

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001038562.1
• Gene: chrna11 / 566141
• ZFINID: ZDB-GENE-060503-606
• Length: 589
• Species: Danio rerio
• Alignment Length: 604
• Identity: 206/604 - (34%)
• Similarity: 310/604 - (51%)
• Gaps: 107/604 - (17%)

  Fly     1 MVHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVE 65
            ::..:|.| |..:.|..:||.:||::.|||.|.:..|.|.:.:.|.|::||:.|||::|||:|:.
Zfish    15 LIQVSVQG-PYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMDVDEKNQVLTTNIWLN 78

  Fly    66 QSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPA 130
            ..|||:.|:|...||.||..|...:|.:|.|||:|||:||..|:.|..:...:.|.|...:.||.
Zfish    79 MHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSNVVVNSSGYCNYLPPG 143

  Fly   131 IYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDI 195
            |:.|:|.:||.:||||.|.|.|||||||:||:.:||: |:|          .|:|.:..:.|||:
Zfish   144 IFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQ-MNE----------ADISGYMPNGEWDL 197

  Fly   196 LEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVT 260
            :.||..|||.||.||.|||.|:||.:|:||:||:|.:|::|||:.:|.:|:|.|.||:|||||::
Zfish   198 VGVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSMTLLIFLLPADSGEKIS 262

  Fly   261 LSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMA 325
            |.|::|:||.||.|||.||:|.||..:||:|:|....||:|.:|:..|||||..|...|....|.
Zfish   263 LGITVLLSLTVFMLLVAEIMPATSDSIPLIGQYFASIMIIVGMSVIATVVVLQYHHHDPNGGNMP 327

  Fly   326 PWVKRVFIDFLPAFLFIKRP--------------------------------------TYNFETS 352
            .||:.|.:.::..||.:|||                                      .::..:|
Zfish   328 KWVQLVLLQWVAWFLRMKRPGESEDPERPPCAPHLRRCSSGSQSGSLPNAPGSASADLHHHHISS 392

  Fly   353 KL-------LLKDTHACFYPYY------SATNIDRLVSSGYNN---SLPKEDLSQSITANGPFGG 401
            .|       ||:...|..:.::      ||.|...|:..|:::   :.|...|:.|:..|...||
Zfish   393 TLHPLHPQSLLQAAAAAGHTHHLHNQTNSANNNGNLLYIGFSSLDEASPPALLADSVQRNSMSGG 457

  Fly   402 ------SCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFC-- 458
                  |..|.|..|| .|..|...:..|          .|..|..|......:......|.|
Zfish   458 PRPTVVSPPVVGSSPP-PHLPSQFCSPPP----------PPTPNLEATGCPSTVSGGGGGCSCSG 511

  Fly   459 ---------------VRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQ 508
                           ||::|:..:.|:::..|.|.||:.|.|:|||.|..|::..::.|..|::.
Zfish   512 TSGGGDPQLQAILEEVRYVADRFRGQDENESVTEQWKFAAAVIDRLCLVAFSVFNIICTISILMS 576

  Fly   509 APTLYDDRIPIIEQKDLDF 527
            ||.       .:|....||
Zfish   577 APN-------FVEAVSKDF 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	200/580 (34%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	96/217 (44%)
		Cys-loop	136..150	CDD:349832	8/13 (62%)
chrna11	NP_001038562.1	LIC	2..577	CDD:455710	201/584 (34%)