Protein Alignment nAChRalpha4 and chrna10a

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_021337092.1
• Gene: chrna10a / 556507
• ZFINID: ZDB-GENE-060503-725
• Length: 532
• Species: Danio rerio
• Alignment Length: 559
• Identity: 183/559 - (32%)
• Similarity: 283/559 - (50%)
• Gaps: 124/559 - (22%)

  Fly    12 AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76
            |::|.:||.:||...:|||.:|.|:|.|.:::.|||:||::.:|||:|..||:.|.|.|..|.|.
Zfish    30 AQKLLNDLFNNYTSALRPVEDTEDILNVTLQITLSQIIDMDERNQILTAYLWIRQVWIDKYLTWN 94

  Fly    77 PKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVE 141
            .:.|.|:..:.:|..::|||||||||:||.:|..|:.|...|..:|.:.|..|||.||||::||.
Zfish    95 KENYDGLDTIRIPGSYVWRPDIVLYNSADDHFTSTMDTNVVIRHDGQIMWDAPAITKSSCKVDVS 159

  Fly   142 YFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKF 206
            :||||.|.|.|.:|||||:|.::|:.:..|         ..||::...:|||::|.:||.||...
Zfish   160 FFPFDAQQCRLTYGSWTYNGNQLDILNAME---------SADLADLVDNVEWEVLGMPAKRNIIL 215

  Fly   207 YTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHV 271
            |.||.:||.|:|:.:.::|:..||..|::|||:.||||..|.||||:||||||:|.::::::|.|
Zfish   216 YGCCADPYPDVTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPADSGEKVSLGVTVMLALTV 280

  Fly   272 FFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFL 336
            |.|||.||:|| |..|||:|||.|..|.:::.|..:|:.|:|:|...|....:..|.|:..:.:|
Zfish   281 FQLLVAEIMPP-SENVPLIGKYYIATMTMITASTALTIFVMNIHHCGPDAKPVPDWAKKFILQYL 344

  Fly   337 PAFLFI-------------------KRP----------------TYNFE-----TSKLLLKDTHA 361
            ....|:                   ::|                .:.|:     ||..||:|
Zfish   345 ARICFVYEVGENCMTPQPEKPDPQPQKPQDCNCNMNGQAGKDDFVFKFDRNQEATSPKLLED--- 406

  Fly   362 CFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDM 426
                                    :||:||.::.      :|.: |..|...:....| .....|
Zfish   407 ------------------------REDMSQILSP------ACSL-GKHPTCRYGVWKE-GVFMSM 439

  Fly   427 DIG--------PLGMKSPILNNPAFSHSKCLPKIHKS-----CFC--------VRFIAEHTKMQE 470
            |.|        |:|.          ....|  :.|.|     |.|        :.::|...:.|.
Zfish   440 DCGDGAAETGKPIGR----------GQEGC--RDHDSGFKSQCKCDQQHLLRNIEYVANCYRDQR 492

  Fly   471 DSTKVKEDWKYVAMVLDRLFLWIFTLAV------VVGTA 503
            .:.:...:||.||.||||.|:|:|.:.|      ::|.|
Zfish   493 ATARRTGEWKKVAKVLDRFFMWLFFIMVFFMSLLIMGKA 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	183/559 (33%)
		Neur_chan_LBD	12..227	CDD:280998	91/214 (43%)
		Neur_chan_memb	234..505	CDD:280999	89/337 (26%)
chrna10a	XP_021337092.1	Neur_chan_LBD	31..422	CDD:332142	153/434 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810