Protein Alignment nAChRalpha4 and CHRNA9

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_060051.2
• Gene: CHRNA9 / 55584
• HGNCID: 14079
• Length: 479
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 191/508 - (37%)
• Similarity: 284/508 - (55%)
• Gaps: 70/508 - (13%)

  Fly    12 AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76
            |::|::||..:|:..:|||.:|..||.|.:::.|||:.|::.:|||:|..||:.|.|:|..|.|:
Human    31 AQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWD 95

  Fly    77 PKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVE 141
            ..:|.|:..:.:|||.:|||||||||.||......:.|...:..:||:.|..|||.||||.:||.
Human    96 RDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVT 160

  Fly   142 YFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKF 206
            |||||.|.|.|.||||||:|.:||:        .|.:..| |||:|...|||::..:|||:|...
Human   161 YFPFDNQQCNLTFGSWTYNGNQVDI--------FNALDSG-DLSDFIEDVEWEVHGMPAVKNVIS 216

  Fly   207 YTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHV 271
            |.||.|||.|:||.:.::|::.||.||::|||:.||||..|:||||:.|||||:|.::||:::.|
Human   217 YGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTV 281

  Fly   272 FFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFL 336
            |.|:|.||: |.|..|||:|||.|..|.|::.|..:|::|:|:||...:...:..|.:.|.:.::
Human   282 FQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYM 345

  Fly   337 PAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPK--------EDLSQSI 393
            ...||:    |:...|         |..|::|... |.|..  ..:.||:        :|||:..
Human   346 SRVLFV----YDVGES---------CLSPHHSRER-DHLTK--VYSKLPESNLKAARNKDLSRKK 394

  Fly   394 TANGPFGG--SCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSC 456
            ..|.....  .||...|....::|:..::                :..|..:. :||| |.||
Human   395 DMNKRLKNDLGCQGKNPQEAESYCAQYKV----------------LTRNIEYI-AKCL-KDHK-- 439

  Fly   457 FCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQA 509
                  |.::|..|        ||.||.|:||.|:|||.:.|.|.|..||.:|
Human   440 ------ATNSKGSE--------WKKVAKVIDRFFMWIFFIMVFVMTILIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	188/502 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	96/216 (44%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
CHRNA9	NP_060051.2	LIC	10..474	CDD:455710	188/502 (37%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	96/214 (45%)
		Cys-loop	155..169	CDD:349823	9/13 (69%)