Protein Alignment nAChRalpha4 and chrna6

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001036149.1
• Gene: chrna6 / 555747
• ZFINID: ZDB-GENE-090312-91
• Length: 512
• Species: Danio rerio
• Alignment Length: 509
• Identity: 228/509 - (44%)
• Similarity: 311/509 - (61%)
• Gaps: 46/509 - (9%)

  Fly    14 RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            ||:..|...||:.:|||.|.:|.:.|..::.:|||:.|:..||||.||||:...|.||||:|.|.
Zfish    29 RLFRRLFRRYNQFIRPVENVSDPVTVEFEVSISQLVKVDEVNQIMETNLWLRHIWNDYKLKWSPA 93

  Fly    79 EYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYF 143
            |:.|:..:.|||:.||||||||||||.|:|.|...|||.:..:|.:.|.||||:||||.:|:.||
Zfish    94 EFDGIEFIRVPSNKIWRPDIVLYNNAVGDFLVEDKTKALLKFDGTITWVPPAIFKSSCPMDITYF 158

  Fly   144 PFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVG--VDLSEFYMSVEWDILEVPAVRNEKF 206
            |||.|.|.:||||||||..|:||           |.:|  |:|.:|:.|.||:|::.|..:::..
Zfish   159 PFDYQNCSMKFGSWTYDKAKIDL-----------VLIGSKVNLKDFWESGEWEIIDAPGYKHDIK 212

  Fly   207 YTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHV 271
            |.||:|.|.|||::..:||..||||:|:||||:.|||||||.||||||.||||||.||:|:||.|
Zfish   213 YNCCEEIYPDITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTV 277

  Fly   272 FFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFL 336
            |.|::.|.||.||||:||:|:||:|.||.|::||.:||.|||||:|:|.||.|..||..||:..|
Zfish   278 FLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMTHTMPSWVHTVFLRAL 342

  Fly   337 PAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANG-PFG 400
            |..:.::||....|:|.....:|...     |.|...|    |......|...||....|. .||
Zfish   343 PRIMLMRRPLDLSESSGKGGLETGGS-----SGTGAGR----GGEGKKRKNSGSQQGAMNSLEFG 398

  Fly   401 ----------GSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMK-SPILNNPAFSHSKCLPKIHK 454
                      |.|..|    ||...:        :.|.|.:..: ||...|...:.|...|:|.:
Zfish   399 EGKAALEGKKGGCPCH----PLKEAT--------EGDCGKVSRQLSPQAINTVVAFSVVSPEIKQ 451

  Fly   455 SCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQ 508
            :...|::|||:.:.:..:.:|::||||||||:||:|||:|.|..|:||.|:.||
Zfish   452 AIESVKYIAENMRSRNKAKEVEDDWKYVAMVIDRIFLWVFVLVCVLGTLGLFLQ 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	225/504 (45%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	102/216 (47%)
		Cys-loop	136..150	CDD:349832	8/13 (62%)
chrna6	NP_001036149.1	LIC	38..504	CDD:455710	223/497 (45%)
		LGIC_ECD	38..233	CDD:475126	99/205 (48%)