Protein Alignment nAChRalpha4 and chrna5

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001017885.1
• Gene: chrna5 / 550584
• ZFINID: ZDB-GENE-050417-440
• Length: 466
• Species: Danio rerio
• Alignment Length: 505
• Identity: 202/505 - (40%)
• Similarity: 286/505 - (56%)
• Gaps: 96/505 - (19%)

  Fly    14 RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            :|:..|.|||.|.|||:.:....::|...|.:|||:||:.|||:||||:|::|.|.|.||||:|.
Zfish    38 KLFKHLFSNYQKWVRPIEDLNTTIQVKFGLAISQLVDVDEKNQLMTTNVWMKQEWTDLKLRWDPD 102

  Fly    79 EYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYF 143
            .|.|:..:.||||.||.||||||:|||||||.|: |||.:..:|.:.|.|||.|||:|.|||.:|
Zfish   103 HYLGITSIRVPSDSIWIPDIVLYDNADGNFEATV-TKAVVRFDGTISWTPPANYKSACTIDVTFF 166

  Fly   144 PFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEK--- 205
            |||.|.|.:|||||||||.:||:...|         |.||..:::.:.||:|::....|..:
Zfish   167 PFDLQNCSMKFGSWTYDGSQVDILLED---------VHVDKRDYFDNGEWEIVKATGNRGLRRDG 222

  Fly   206 -FYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISL 269
             |:      |..||::..:||..||||:.:||||:|:||||||.|||||:.|||::|..|:|:||
Zfish   223 TFF------YPSITYSFIIRRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNGGEKISLCTSVLVSL 281

  Fly   270 HVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQT-HKMAPWVKRVFI 333
            .||.|::.||||.:|.|:||:|:||:|.||.|::||.:||..:|:|.||..| |.|||||:|:|:
Zfish   282 TVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSSTHHSMAPWVRRIFL 346

  Fly   334 DFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGP 398
            ..||               :||...:|...|...:.|....|   ||..|| .:|.:|
Zfish   347 HHLP---------------RLLCMRSHVDRYATSAGTRTGGL---GYGKSL-SQDTNQ------- 385

  Fly   399 FGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIA 463
                                       :|.               .|:     :..:...:|:|.
Zfish   386 ---------------------------LDA---------------EHN-----LQAALESIRYIT 403

  Fly   464 EHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLY 513
            .|...:.:..:|.:|||:||.||||:|||.|.|..::|:|  :|..|.:|
Zfish   404 RHVVKENEVREVVQDWKFVAQVLDRVFLWAFLLVSLLGSA--LLFIPVIY 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	199/495 (40%)
		Neur_chan_LBD	12..227	CDD:280998	100/216 (46%)
		Neur_chan_memb	234..505	CDD:280999	95/271 (35%)
chrna5	NP_001017885.1	LIC	12..448	CDD:273305	200/500 (40%)
		Neur_chan_LBD	36..239	CDD:280998	100/216 (46%)
		Neur_chan_memb	246..446	CDD:280999	95/274 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830