Protein Alignment nAChRalpha4 and Chrnd

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_062171.1
• Gene: Chrnd / 54240
• RGDID: 2352
• Length: 517
• Species: Rattus norvegicus
• Alignment Length: 533
• Identity: 177/533 - (33%)
• Similarity: 281/533 - (52%)
• Gaps: 65/533 - (12%)

  Fly     8 GNPDAKRLYDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70
            |..:.:||...|.  ..|||.:|||....|::.|.:.|.||.||.:....:.:|||:|::.:|.|
  Rat    21 GLNEEQRLIQHLFEEKGYNKELRPVARKEDIVDVALSLTLSNLISLKEVEETLTTNVWIDHAWID 85

  Fly    71 YKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSS 135
            .:|:|...|:|.:.:|.:|||.:|.|:|||.||.||:|:::.|....:...|.|.|.||||::||
  Rat    86 SRLQWNANEFGNITVLRLPSDMVWLPEIVLENNNDGSFQISYACNVLVSDSGHVTWLPPAIFRSS 150

  Fly   136 CEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSN---VVAVGVDLSEFYMSVEWDILE 197
            |.|.|.|||||.|.|.|||.|..|...::.|....|::.:.   :..:.:|...|..:.||:|:.
  Rat   151 CPISVTYFPFDWQNCSLKFSSLKYTAKEIRLSLKQEEEDNRSYPIEWIIIDPEGFTENGEWEIVH 215

  Fly   198 VPAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTL 261
            ..|..|.......|.. :.|:||.:.:|||.|||.:||::||:.|||:..|.||||.|.|||.::
  Rat   216 RAAKVNVDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISFMINLVFYLPGDCGEKTSV 280

  Fly   262 SISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAP 326
            :||:|::..||.||:.:.:|.||:.:||:||:|:|.|:||::.:.:.|:|||:|||:|.||.::.
  Rat   281 AISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSE 345

  Fly   327 WVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFY-----PYYSATNIDRLVSSGYNNSLPK 386
            .||:.|::.||..|.:.||.......:.|::.|.:..|     .|:|..:...|:   :.....:
  Rat   346 GVKKFFLETLPKLLHMSRPEEEDPGPRALIRRTSSLGYISKAEEYFSLKSRSDLM---FEKQSER 407

  Fly   387 EDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPK 451
            ..|::.:|.           ...||   .||:::                  ....|:..|  |.
  Rat   408 HGLARRLTT-----------ARKPP---ASSEQV------------------QQELFNEMK--PA 438

  Fly   452 IHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQA------- 509
            :..:    .||..|.:.|....:.|::|..||..:|||.|::.|..:|||||.|.||.
  Rat   439 VDGA----NFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPP 499

  Fly   510 ------PTLYDDR 516
                  |..||::
  Rat   500 QPFPGDPFSYDEQ 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	171/507 (34%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	81/223 (36%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
Chrnd	NP_062171.1	LGIC_ECD	26..246	CDD:475126	80/219 (37%)
		Neur_chan_memb	253..489	CDD:460753	85/276 (31%)