DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha4 and Chrnb2

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_062170.1	Gene:	Chrnb2 / 54239	RGDID:	2350	Length:	500	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	219/513 - (42%)
Similarity:	304/513 - (59%)	Gaps:	66/513 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VAGNPDAKRLYDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSW 68
            |.|....:||.:.||  |.||||:||..|.::::.|.:.:.|:|||.|:.:.||||||:|:.|.|
  Rat    22 VLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEW 86

  Fly    69 YDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYK 133
            .||:|.|:|:::..:..:.:||.|||.||:||||||||.:||:..:.|.:..:|.:.|.||||||
  Rat    87 EDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYK 151

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGV-DLSEFYMSVEWDILE 197
            |:|:|:|::||||:|.|.:||.|||||..::||          |:...| .|.:|..|.||||:.
  Rat   152 SACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL----------VLKSDVASLDDFTPSGEWDIIA 206

  Fly   198 VPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLS 262
            :|..|||   ...|..|:|||::..:|||.||||:|:||||:.|:.|.:|.||||||.|||:||.
  Rat   207 LPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLC 268

  Fly   263 ISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPW 327
            ||:|::|.||.||:.:|:|||||.|||:||||:|.|:||:.||..:|.|||||.|||.||.||||
  Rat   269 ISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPW 333

  Fly   328 VKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQS 392
            ||.||::.||..||:::|.:.....:|.|:                       .....:|.....
  Rat   334 VKVVFLEKLPTLLFLQQPRHRCARQRLRLR-----------------------RRQREREGAGAL 375

  Fly   393 ITANGPFGGSC-------QVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLP 450
            ....||....|       .|.|.....   .::..||.|...:||                 |..
  Rat   376 FFREGPAADPCTCFVNPASVQGLAGAF---RAEPTAAGPGRSVGP-----------------CSC 420

  Fly   451 KIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQ 508
            .:.::...|||||:|.:.::|...|:|||||||||:||||||||....|.||.|:.||
  Rat   421 GLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTVGMFLQ 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	216/508 (43%)
		Neur_chan_LBD	12..227	CDD:280998	97/217 (45%)
		Neur_chan_memb	234..505	CDD:280999	111/277 (40%)
Chrnb2	NP_062170.1	LIC	28..477	CDD:273305	215/504 (43%)
		Neur_chan_LBD	28..233	CDD:280998	97/217 (45%)
		Neur_chan_memb	240..476	CDD:280999	112/278 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9116
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820