DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and chrne

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_001314812.1 Gene:chrne / 445315 ZFINID:ZDB-GENE-040808-32 Length:517 Species:Danio rerio


Alignment Length:533 Identity:177/533 - (33%)
Similarity:272/533 - (51%) Gaps:81/533 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70
            |.||.:: :|..|...||:|.:||..:..:.:||.:||.|:.||.:|.|.:.:|||:|:|..|:|
Zfish    24 VTGNEES-QLIADKFKNYSKNIRPARHADEKVKVQVKLTLTNLISLNEKEETLTTNVWIEIQWHD 87

  Fly    71 YKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSS 135
            |:|.|...||..:..:.||...:|.|||||.||.||.|:|.......|.|:|.:.|.|||||:|:
Zfish    88 YRLAWNTSEYHDIEQIRVPYYTVWLPDIVLENNIDGKFDVAYYANVLISSDGSMYWLPPAIYRST 152

  Fly   136 CEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPA 200
            |.|::.|||||.|.|.|.|.|.||...::|:...:::.|..:..|.:|...|..:.||.|...||
Zfish   153 CAIEITYFPFDWQNCTLVFRSQTYSANEIDIVLAEDENGKPIEWVDIDPEAFTENGEWAIKHRPA 217

  Fly   201 --VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS-GEKVTLS 262
              :.|:: |:..|..|.::.:||.::||.|||.:|||:||..||.|.||.::||:.: |:|:|:|
Zfish   218 RKLTNQR-YSPDDLEYQEVYYNIIIQRKPLFYVINIILPCSLISSLVVLAYFLPAKAGGQKLTVS 281

  Fly   263 ISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPW 327
            ||:|::..||.:|:.:.||.|||.|||:||||||.|.:.::.:...::|||...|||.||.|:..
Zfish   282 ISVLLAQTVFLILISQKIPETSLSVPLIGKYLIFVMSMTTLIVTNCIIVLNYSLRSPSTHNMSQS 346

  Fly   328 VKRVFIDFLPAFL----FI--------------KRPTYNF--ETSKLLLKDTHACFYPYYSATNI 372
            :|.:|::.:|.:|    |:              :|.::..  ...:.:||.              
Zfish   347 IKHIFLEVVPRYLGMAPFVDEGDQGGVYEMRERRRSSFGLMQRAEEYVLKQ-------------- 397

  Fly   373 DRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPI 437
                        |:.::.        |....:.||    |.....|||      |:....     
Zfish   398 ------------PRSEMM--------FDKQRERHG----LMRTIVDEI------DVSSTA----- 427

  Fly   438 LNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGT 502
              |...|.:|..|:|.:......||||.||.|.|:....|.|..:..::|::..|.......:||
Zfish   428 --NLYKSLAKTAPEIKECVDACNFIAESTKQQNDTGSEMESWVLIGKMIDKVCFWAAISLFSIGT 490

  Fly   503 AGIIL-----QAP 510
            ..|.|     |||
Zfish   491 IAIFLMGHYNQAP 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 172/521 (33%)
Neur_chan_LBD 12..227 CDD:280998 83/216 (38%)
Neur_chan_memb 234..505 CDD:280999 81/291 (28%)
chrneNP_001314812.1 LIC 10..495 CDD:273305 173/523 (33%)
Neur_chan_LBD 29..245 CDD:280998 83/217 (38%)
Neur_chan_memb 252..494 CDD:280999 81/292 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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