Protein Alignment nAChRalpha4 and pHCl-2

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 108/547 - (19%)
• Similarity: 186/547 - (34%)
• Gaps: 180/547 - (32%)

  Fly    23 YNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKN------QIMTTNLWVEQSWYDYKLRWEPKEYG 81
            |:::|.|||:..|..:|.:.:.....|.| :||      |.....| ::..:.|.:|.:..
  Fly    85 YDRMVPPVVHNKDGEEVPMDIYARFYIYV-MKNLDSSDLQFTVQGL-LQLRYLDPRLAFSS---- 143

  Fly    82 GVHMLHVPSDH------------IWRPDIVLYNNADGNFEVTLATKA-----TIYSEGLVEWKPP 129
                 ::|:..            :|.|.|.|.|.   .....|.|.|     :||..|.|.....
  Fly   144 -----YLPNRRQPIMGESELKKMLWVPHIFLTNE---QASTVLGTSAKDELTSIYPNGTVLTSTR 200

  Fly   130 AIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWD 194
            ......|.::.:.||||||.|.....||.|:...|.| |.:.   .|.|:....|    ...|::
  Fly   201 LQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQL-HWET---DNPVSFDKQL----QLTEYN 257

  Fly   195 IL-----EVPAVRNEKF--YTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLP 252
            ::     |...|.||.:  :...:..|..|:|.:.:.|:..:|.::..:|.:.|..::.::|:|.
  Fly   258 LIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQ 322

  Fly   253 SD-SGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHF 316
            :| :..:.||..:.|:|     .:.:.:....:|:     |.....|..|...:|.
  Fly   323 ADQTPARTTLGCTTLLS-----FITLSLSQENNLM-----KVSYVTMSEVWFLVCT--------- 368

  Fly   317 RSPQTHKMAPWVKRVFI-DFLPAFLFIK---RPTYNFE----TSKLLLKDTHACFYPY------- 366
                          :|| ..|..|.|:.   |...:.:    |:|.::|.|   |.|:
  Fly   369 --------------IFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKST---FVPHLKKHRRH 416

  Fly   367 -----------YSATNIDRLVSSGYNNSLPKEDLSQSITANGP--FGGSCQVHGPVPPLTHCSSD 418
                       .|.|::|:  :.|.||::        ||...|  .|||..           ..|
  Fly   417 GYRRTDSTMSTMSTTSMDK--TCGPNNTV--------ITIETPIIIGGSLS-----------RED 460

  Fly   419 EIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVA 483
            ...::.:.|                                   ...|....||:|.|....:..
  Fly   461 SAISLDEQD-----------------------------------ETSTSESSDSSKEKPAQTFAT 490

  Fly   484 MVLDRLFLWI-------FTLAVVVGTA 503
            |....:.|||       |.|:.:|..|
  Fly   491 MTPKEVSLWIDRKMRFVFPLSFIVFNA 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	108/547 (20%)
		Neur_chan_LBD	12..227	CDD:280998	54/233 (23%)
		Neur_chan_memb	234..505	CDD:280999	53/306 (17%)
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	108/547 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030