DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha4 and nAChRbeta2

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	291/516 - (56%)
Similarity:	368/516 - (71%)	Gaps:	48/516 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 73
            |||.||||||||||||:|:|||||.|:.|.|.:.|||||||:||||||:|||||||:|.|:||||
  Fly    27 NPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKL 91

  Fly    74 RWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEI 138
            ||:|:|||||..|:|||:|||.||||||||.|||:||||.||||:...|.|.|:||||||||||:
  Fly    92 RWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEM 156

  Fly   139 DVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRN 203
            :|||||:|||.|.:|||||||:|.:|||:|:|:..|||:|.||:||:|||:|||||||||||.:|
  Fly   157 NVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKN 221

  Fly   204 EKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILIS 268
            |::|....||:.||||.:||||||||||||:|:||:.::|||||.|||||||||||||.||||:|
  Fly   222 EEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVS 286

  Fly   269 LHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFI 333
            |.|||||:.||||||||.||||||||:|.|||||:|:..||.|||:|||||.||.|:|.|:::|:
  Fly   287 LTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFL 351

  Fly   334 DFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGP 398
            .|:|..:.::|..|..               |.|.    |...|:||.|.:   |:..||
  Fly   352 HFMPKLMMMRRTQYTL---------------PDYD----DSTPSNGYTNEI---DVRDSI----- 389

  Fly   399 FGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPL--GMKSPILNNPAFSHSKCLPKIHKSCFCVRF 461
                              ||..:...|...|..  ||::.:.::.....: ..|::.::...|||
  Fly   390 ------------------SDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRN-LTPEVLQALRAVRF 435

  Fly   462 IAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQ 522
            ||:|.|..:...::.||||:|:|||||.|||:|||:.|.||..||.|:|:|||.|.||..|
  Fly   436 IAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQ 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	280/497 (56%)
		Neur_chan_LBD	12..227	CDD:280998	151/214 (71%)
		Neur_chan_memb	234..505	CDD:280999	118/272 (43%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	280/497 (56%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	154/217 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447327
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
	12	11.830