Protein Alignment nAChRalpha4 and GluClalpha

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Alignment Length: 447
• Identity: 98/447 - (21%)
• Similarity: 181/447 - (40%)
• Gaps: 89/447 - (19%)

  Fly    13 KRLYDDLL--SNYNKLVRPV-VNTTD---VLKVCIKLK-LSQLIDVNLKNQIMTTNLWVEQSWYD 70
            |::.|.:|  ..|:..:||. :|.||   |::|.|.:: :|::.||.::..:..|   ..:.|.|
  Fly    34 KKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLT---FREQWTD 95

  Fly    71 YKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKA--TIYSEGLVEWKPPAIYK 133
            .:|:::..:....::....::.:|.||:...|..:|:|...:....  .|:..|.|.:.......
  Fly    96 ERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLT 160

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGS--WTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDIL 196
            .:|.::::.:|.|.|.|.|:..|  ||.:    ||..: .::|..|..|             ..|
  Fly   161 LACPMNLKLYPLDRQICSLRMASYGWTTN----DLVFL-WKEGDPVQVV-------------KNL 207

  Fly   197 EVPAVRNEKFYT-CCDE-----PYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS 255
            .:|....|||.| .|:.     .|..:..::..:|:..:|.:.|.|||..:..::.::|:|  |.
  Fly   208 HLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWL--DQ 270

  Fly   256 G---EKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVV------- 310
            |   .:|:|.::.|:::......:...:||.|..          ..|.|...:|:|.|
  Fly   271 GAVPARVSLGVTTLLTMATQTSGINASLPPVSYT----------KAIDVWTGVCLTFVFGALLEF 325

  Fly   311 -VLNVHFRS----PQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSAT 370
             ::|...||    ...||..  :|:...|...|.|        ...|.||..|::|.|   ..|:
  Fly   326 ALVNYASRSGSNKANMHKEN--MKKKRRDLEQASL--------DAASDLLDTDSNATF---AMAS 377

  Fly   371 NIDRLVSSGYNNSL---PKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVP 424
            ...|  ..|....|   |.:.|:.....      .|:||...|...:|....::..|
  Fly   378 QFAR--GGGQQKPLVRHPGDPLALEKRL------QCEVHMQAPKRPNCCKTWLSKFP 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	98/447 (22%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	51/232 (22%)
		Cys-loop	136..150	CDD:349832	4/13 (31%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	98/447 (22%)