Protein Alignment nAChRalpha4 and HisCl1

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 363
• Identity: 85/363 - (23%)
• Similarity: 139/363 - (38%)
• Gaps: 80/363 - (22%)

  Fly     2 VHGAVAGNPDAKRL---YDDLLS----------NYNK------LVRPVVNTTDVLKVCIKLKLSQ 47
            ||| ...|.::..|   |:..||          .|:|      |.:|.|       |...:.:..
  Fly    34 VHG-YRNNTESAELVSHYESSLSLPDILPIPSKTYDKNRAPKLLGQPTV-------VYFHVTVLS 90

  Fly    48 LIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDH-IWRPDIVLYNNADGNFEVT 111
            |..:|.::....|::::.|||.|.:||..........:|.|...| |||||....|
  Fly    91 LDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDCFFKN--------- 146

  Fly   112 LATKATIYSEGLVE---W---KPPAIYKS------SCEIDVEYFPFDEQTCVLKFGSWTYDGFKV 164
             |.|.|.:...:..   |   ....:|.|      ||.:..|.:|.|.|.|.:...|
  Fly   147 -AKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIES-------- 202

  Fly   165 DLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTC-CDEPY-------LDITFNI 221
             |.|..|    ::|.:........::.|   :|:|.:.....||. |...|       |.|.||
  Fly   203 -LSHTVE----DLVFIWNMTDPLVVNTE---IELPQLDISNNYTTDCTIEYSTGNFTCLAIVFN- 258

  Fly   222 TMRRKTLFYTVNIIIPCMGISFLTVLTFYL-PSDSGEKVTLSISILISLHVFFLLVVEIIPPTSL 285
             :||:..::..:..||...|..::.::|:: |.....:|||.::.|::|........:.:||.|
  Fly   259 -LRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS- 321

  Fly   286 VVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHK 323
            .|..:..::....:.|.:|:....||.|  |..|...|
  Fly   322 YVKAIDVWMSSCSVFVFLSLMEFAVVNN--FMGPVATK 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	85/363 (23%)
		Neur_chan_LBD	12..227	CDD:280998	59/254 (23%)
		Neur_chan_memb	234..505	CDD:280999	22/91 (24%)
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	54/229 (24%)
		Neur_chan_memb	270..>350	CDD:280999	19/82 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100