Protein Alignment nAChRalpha4 and chrnd

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_996947.1
• Gene: chrnd / 404273
• ZFINID: ZDB-GENE-030131-6665
• Length: 518
• Species: Danio rerio
• Alignment Length: 545
• Identity: 186/545 - (34%)
• Similarity: 279/545 - (51%)
• Gaps: 68/545 - (12%)

  Fly     8 GNPDAKRLYDDLLS--NYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70
            |..:.:||.:.|..  .|||.:|||.|..:.:.:.:.|.||.||.:...::.:.||:|:|..|.|
Zfish    21 GRNEEERLINYLFKERGYNKELRPVQNKDETVDIYLALTLSNLISLKEVDETLLTNVWMEHGWKD 85

  Fly    71 YKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSS 135
            ::|.|...|| .:.:|.:|...:|.|:|||.||.|..|:|.......|||.|.:.|.||||::||
Zfish    86 HRLTWNESEY-DIPVLRLPPSMVWLPEIVLENNNDAQFQVAYYCNVLIYSSGDMYWLPPAIFRSS 149

  Fly   136 CEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVG---VDLSEFYMSVEWDILE 197
            |.|:|.|||||.|.|.|||.|.||:..::.|....||:.:....|.   :|...|..:.||:|:.
Zfish   150 CSINVNYFPFDWQNCSLKFSSLTYNAKEISLNLKMEQENTTYYKVEWIIIDPEGFTENGEWEIVH 214

  Fly   198 VPAVRNEKFYTCC---DEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKV 259
            .||.||  .|...   ...:.||||.:.::||.|||.|||||||:.||||..|.:|||:|||||:
Zfish   215 KPARRN--IYKSIPKESNKHQDITFYLIIKRKPLFYIVNIIIPCVLISFLASLVYYLPADSGEKM 277

  Fly   260 TLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKM 324
            |||||:|::..||.||:.:.:|.||:.|||:.|||:|.|:||::.:...|:|||:|||:|.||.|
Zfish   278 TLSISVLLAQSVFLLLISQRLPETSMAVPLIVKYLMFIMVLVTVVVLNCVIVLNLHFRTPSTHVM 342

  Fly   325 APWVKRVFIDFLPAFLFIKRPTYNFETSKLLL-KDTHACFY-----PYYSATNIDRLVSSGYNNS 383
            ..|.|..|::.||..|.:..|..:....:..| :.:.:..|     .|||..:...|:
Zfish   343 TEWTKEFFLERLPRLLHMSLPVEDQPVPESALPRRSSSLGYIAQAEEYYSVKSRSELM------- 400

  Fly   384 LPKEDLSQSITANGPFGGSCQVHG----PVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFS 444
                           |....:.||    |.|..|:.||::......:
Zfish   401 ---------------FEKQSERHGLAARPTPKATYTSSNDSEVSEQL------------------ 432

  Fly   445 HSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQA 509
            :::..|.:..:    .:|.:|...:.|..:.|::|..:|..:|||..::.|..:::||..|.|.|
Zfish   433 YNEMKPAVEGA----NYIVKHMHDKNDYNEEKDNWSGIARTVDRLCFYVVTPVMMIGTICIFLMA 493

  Fly   510 PTLYDDRIPIIEQKDLDFSGTSAGR 534
            .......:|.  |.| .||.|...|
Zfish   494 NYNQPPALPF--QGD-PFSYTEENR 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	176/514 (34%)
		Neur_chan_LBD	12..227	CDD:280998	83/222 (37%)
		Neur_chan_memb	234..505	CDD:280999	86/280 (31%)
chrnd	NP_996947.1	LIC	6..493	CDD:273305	178/518 (34%)
		Neur_chan_LBD	25..245	CDD:280998	83/222 (37%)
		Neur_chan_memb	252..490	CDD:280999	86/281 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810