Protein Alignment nAChRalpha4 and SecCl

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 91/484 - (18%)
• Similarity: 179/484 - (36%)
• Gaps: 138/484 - (28%)

  Fly     5 AVAGNPDAKRLYDDL--LSNYNKLVRPVVNTTD--VLKVCIKLKLSQLIDVNLKNQIMTTNL--W 63
            |.||:....:|...|  :..|::|.||....:|  .|.:.:|.::......||.:.::...:  .
  Fly    37 ADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHAL 101

  Fly    64 VEQSWYDYKLRWE-----PKEYGGVHMLHVPSDHIWRPDIVLYN------------------NAD 105
            ::..:.|.:|.::     ....|..|:    |:.:|.|.|...|                  :.:
  Fly   102 LQLRFQDKRLAYKAFNRSDNILGQKHL----SERLWLPHIFFANERESSILGTDEKDVLTSLSPE 162

  Fly   106 GNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYD---------- 160
            ||..::...:|::|                |.::.:.||||:|.|.....||.|:
  Fly   163 GNVIISTRMQASLY----------------CWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEP 211

  Fly   161 ----GFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEW----------DILEVPAVRNEKFYTCCD 211
                .|..::|                |:|:.|:..|          |.|...|....
  Fly   212 HTPISFDPEMR----------------LTEYNMAQFWHNTTIVQSDGDNLRHGAFAGN------- 253

  Fly   212 EPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSD-SGEKVTLSISILISLHVFFLL 275
              |..::|.:.::|:..||.::..:|.|.|..::.::|:|.:| |..::.|..|.::|.......
  Fly   254 --YSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSS 316

  Fly   276 VVEIIPPTSLV----VPLLG-KYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDF 335
            ..:.:|..|.:    |..|| .:.||..:       |....:|..:|..:..::    |:|...:
  Fly   317 QSKNLPKVSYIKVSEVWFLGCTFFIFGSL-------VEFAFVNTIWRRKENIEL----KKVNSKY 370

  Fly   336 LPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSI-----TA 395
            :.......||... :....|..::.|     .|.:::|.:|||           ::|:     |.
  Fly   371 IIKSTLTPRPARR-QIGGSLSNESRA-----RSCSSLDNIVSS-----------TESVRNGNGTV 418

  Fly   396 NGPFGGSCQVHGPVPPL-THCSSDEIAAV 423
            |..|.....||..:|.: |.|:..:..::
  Fly   419 NQGFNNYLTVHPNLPIIRTECAEADTVSI 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	91/484 (19%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	46/270 (17%)
		Cys-loop	136..150	CDD:349832	6/13 (46%)
SecCl	NP_648984.2	LIC	43..505	CDD:455710	88/478 (18%)