DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and chrna1.2

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:XP_012825723.1 Gene:chrna1.2 / 394991 XenbaseID:XB-GENE-5932067 Length:457 Species:Xenopus tropicalis


Alignment Length:517 Identity:206/517 - (39%)
Similarity:293/517 - (56%) Gaps:92/517 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 GAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSW 68
            |.|..:....||..||.:||||:||||....|.:.|.:.|:|.|||:|:..|||::||:.::|.|
 Frog    16 GPVFSSDHETRLIGDLFANYNKVVRPVETYKDQVVVTVGLQLIQLINVDEVNQIVSTNIRLKQQW 80

  Fly    69 YDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYK 133
            .|..|:|:|.:||||..|.:||..:|.||:||||||||:|.::..||..:...|.:.|.||||:|
 Frog    81 VDVNLKWDPAKYGGVKKLRIPSSEVWCPDLVLYNNADGDFAISKDTKILLEHTGKITWTPPAIFK 145

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEV 198
            |.|||.|.:||||:|.|.:|||:|||||..|.:....::.         |||.|..|.||.:.:.
 Frog   146 SYCEIIVTHFPFDQQNCSMKFGTWTYDGTLVVINPDRDRP---------DLSNFMASGEWMMKDY 201

  Fly   199 PAVRNEKFYTCC-DEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLS 262
            ...::..:|||| |:||||||::..::|..|::.||:||||:..||||.|.||||:|||||:|||
 Frog   202 RCWKHWVYYTCCPDKPYLDITYHFVLQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLS 266

  Fly   263 ISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPW 327
            ||:|:||.||.|::||:||.||..|||:|||::|.|:.|..||.:||:|:|.|.|||.||.|.||
 Frog   267 ISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHTMPPW 331

  Fly   328 VKRVFIDFLPAFLF---IKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDL 389
            |:::|||.:|..:|   :|||:                                       :|..
 Frog   332 VRKIFIDTIPNIMFFSTMKRPS---------------------------------------QEKQ 357

  Fly   390 SQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDI----GPLGMKSPILNNPAFSHSKCLP 450
            .|:..|.                            :|||    |.||..:....:||..:    |
 Frog   358 PQTTFAE----------------------------EMDISDISGKLGPAAVTYQSPALKN----P 390

  Fly   451 KIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGT----AGIILQ 508
            .:..:...:::|||..|..::|.|..|:||:||||||.:.|.:|....|:||    ||.|::
 Frog   391 DVKSAIEGIKYIAETMKSDQESNKASEEWKFVAMVLDHILLAVFMTVCVIGTLAVFAGRIIE 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 204/512 (40%)
Neur_chan_LBD 12..227 CDD:280998 98/215 (46%)
Neur_chan_memb 234..505 CDD:280999 101/281 (36%)
chrna1.2XP_012825723.1 LIC 8..447 CDD:273305 203/510 (40%)
LGIC_ECD_nAChR_A1 22..231 CDD:349815 98/217 (45%)
Cys-loop 148..162 CDD:349815 9/13 (69%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.110

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