Protein Alignment nAChRalpha4 and chrna7a

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_957513.1
• Gene: chrna7a / 394199
• ZFINID: ZDB-GENE-040108-3
• Length: 509
• Species: Danio rerio
• Alignment Length: 508
• Identity: 200/508 - (39%)
• Similarity: 298/508 - (58%)
• Gaps: 39/508 - (7%)

  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            :|||.||:.:||.|.|||.|.|..|.|...:.|.|::||:.|||::|||:|::..||||.|:|..
Zfish    27 RRLYRDLMKDYNPLERPVFNDTHSLTVYFSMSLMQIMDVDEKNQVLTTNIWLQLYWYDYYLQWNA 91

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEY 142
            .||.||..:..|...||:|||:|||:||..|:.|..|...:.|.|..::.||.|:||:|.|||.:
Zfish    92 SEYPGVTNVRFPDSQIWKPDILLYNSADERFDATFHTNVLVNSSGACQYLPPGIFKSTCYIDVRW 156

  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFY 207
            ||||.|.|.||||||||.|:.:||:.:|           .|::.:..:.|||::|||..|||:||
Zfish   157 FPFDLQRCDLKFGSWTYGGWSLDLQMID-----------ADITGYIANGEWDLVEVPGRRNERFY 210

  Fly   208 TCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVF 272
            .||.|||.|:||.:.|||:||:|.:|::|||:.||.|.:|.|.||:|||||::|.|::|:||.||
Zfish   211 DCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVF 275

  Fly   273 FLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLP 337
            .|||.||:|.||..|||:.:|....|::|.:|:..||.||..|:..|:..||..|.:.|.:::..
Zfish   276 MLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPEGGKMPKWTRVVLLNWCA 340

  Fly   338 AFLFIKRPTYNFETSKLLLKDTHACF--YPYYSATNIDRLVSSGYNNSLPKEDLSQSITAN---- 396
            .||.:|||..:        |...||.  .|..|.:::|..:|.|         ::||...|
Zfish   341 WFLRMKRPGED--------KVRPACHNKQPRSSLSSVDLNISPG---------VAQSTNGNLLYI 388

  Fly   397 GPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRF 461
            | |.|...:|....|.:......:.|..:.|:...|.::..:::.....:: |.||...   ||:
Zfish   389 G-FRGMDTIHYATSPDSGVICSRLVATGEEDVLLPGAQASSVSSSGPGETE-LSKILDE---VRY 448

  Fly   462 IAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYD 514
            |::..:.|::...|..:||:.|.|:|||.|..|:|..::.|.||::.||...:
Zfish   449 ISKRFRDQDEEDTVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSAPNFVE 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	196/497 (39%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	103/215 (48%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
chrna7a	NP_957513.1	LIC	3..496	CDD:455710	198/501 (40%)