Protein Alignment nAChRalpha4 and lgc-29

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001317792.1
• Gene: lgc-29 / 3896858
• WormBaseID: WBGene00044528
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 338
• Identity: 76/338 - (22%)
• Similarity: 148/338 - (43%)
• Gaps: 56/338 - (16%)

  Fly     8 GNPDAKRLYDDLLSNYNKLVRPVVNTTDV-----------LKVCIKLKLSQLIDVNLKNQIMTTN 61
            |:.|  ||::.|..:|:..:..:.....|           .::.|:|.:.:|::|....:..|..
 Worm    36 GHQD--RLFEKLFKSYDPGINAIYTLHSVPETNGTVHPPRFEITIQLSMMKLVEVVEPEEKATFL 98

  Fly    62 LWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVL---YNNADGNFEVTLATKATIYSEGL 123
            ......|||.:|.|:|::|||::.::||...:|.|:..:   :::....|:......|.::|.|.
 Worm    99 FDYRADWYDTRLSWDPEDYGGINHIYVPRSKVWIPETTIVDCFSSEIKVFDNEYTRYAWLHSNGS 163

  Fly   124 VEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYD-------GFKVDLRHMDEQQGSNVVAVG 181
            :.....::....|::||..||.|..||.:.|...||.       |....|....||.|:.
 Worm   164 IGMYIASVTSVVCQMDVYKFPMDTHTCSVNFLFMTYQLEEFTIVGKTGTLPRPVEQLGNG----- 223

  Fly   182 VDLSEFYMSVEWDILEV-----PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGI 241
                      ||.:..:     |.|.|..:.|         .|..|..|...||.|.::||...|
 Worm   224 ----------EWQMKSIQIAFEPVVDNLTYLT---------KFEATFSRNPGFYIVLVMIPAYFI 269

  Fly   242 SFLTVLTFYLP-SDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLI--FAMILVSI 303
            :.|:::..::. ::..||.|:.::.::|:....:::.|.:|.|. .:|:|..|.:  .|::|.|:
 Worm   270 NVLSIVALFMDINNRSEKFTVGMTNIMSMSFILVILAEDLPKTK-NLPILAIYTVTSLAIMLCSL 333

  Fly   304 SICVTVVVLNVHF 316
            :..|.:..|..::
 Worm   334 TAVVALPKLKAYY 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	76/338 (22%)
		Neur_chan_LBD	12..227	CDD:280998	52/240 (22%)
		Neur_chan_memb	234..505	CDD:280999	19/86 (22%)
lgc-29	NP_001317792.1	LIC	38..>337	CDD:273305	73/325 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810