Protein Alignment nAChRalpha4 and lgc-8

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001023533.2
• Gene: lgc-8 / 3564870
• WormBaseID: WBGene00013338
• Length: 438
• Species: Caenorhabditis elegans
• Alignment Length: 341
• Identity: 82/341 - (24%)
• Similarity: 164/341 - (48%)
• Gaps: 41/341 - (12%)

  Fly    12 AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76
            :::|.|.|:..|:..:|||:|..|.|.:.|.:.....:.::...:.:..:......|.|..|.|.
 Worm    28 SEQLKDVLMEGYDSSIRPVINERDTLFINISINSMSFLTLDPAEETINFSGEFILQWKDEFLFWN 92

  Fly    77 PKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATK-ATIYSEGLVEWKPPAIYKSSCEIDV 140
            ..:| .:..|.:....:|.||..:..:.|.|:.:..:.: .::..:|.|.....|::.:.|::::
 Worm    93 KSDY-NITWLKLKESFLWTPDTTVSTSIDTNYLIETSERYVSVKYDGTVRQNIYAVFTNLCDMNI 156

  Fly   141 EYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDL------SEFYMSVEWDILEVP 199
            ..||:|:|||::|.|.|:|...:|            ...||.|:      .:|..:.|||...:.
 Worm   157 NEFPYDQQTCMIKMGPWSYTMKEV------------TCIVGGDIERNETTGKFQGNSEWDFEGIV 209

  Fly   200 AVRNEKFYTCCDEPYLDITFN-----ITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS---- 255
            :...|     .::|.::.||:     :|::|:..||...::||...|:.:.:...:.|:.:
 Worm   210 SSVGE-----TEDPDVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIITVVCIFGLFTPTANHGLR 269

  Fly   256 GEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQ 320
            .|:|.|.|:.|:|..|...:|...:|.|| .:||||.:::..:.:|:|.:...|:||.:|.|: .
 Worm   270 EERVNLGITTLLSSAVILQIVANAMPKTS-ELPLLGNFILAEIFVVAIGVLFAVLVLTLHQRA-H 332

  Fly   321 THKMAP-----WVKRV 331
            |.:..|     |:.|:
 Worm   333 TREWRPPAWMLWILRM 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	82/341 (24%)
		Neur_chan_LBD	12..227	CDD:280998	50/226 (22%)
		Neur_chan_memb	234..505	CDD:280999	30/107 (28%)
lgc-8	NP_001023533.2	Neur_chan_LBD	29..237	CDD:280998	50/225 (22%)
		Neur_chan_memb	244..>348	CDD:280999	29/105 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810