DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha4 and ZACN

DIOPT Version :10

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_851321.2 Gene:ZACN / 353174 HGNCID:29504 Length:412 Species:Homo sapiens


Alignment Length:349 Identity:73/349 - (20%)
Similarity:149/349 - (42%) Gaps:63/349 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVHGAVAGNPDAKRLYDDLLS-NYNKLVRPVV----NTTDVLKVCIKLKLSQLIDVNLKNQIMTT 60
            :|||  .|......::..|.: |.:|.|:..:    |.:..|.|.:::.:|.:.:|::....|::
Human    21 LVHG--QGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSS 83

  Fly    61 NLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYN---------------NADGNFEV 110
            .|.:..||.|.:|.|....:.. |.:.:|.:.:|.|.:.:..               :.||:.::
Human    84 MLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTILEALWVDWRDQSPQARVDQDGHVKL 147

  Fly   111 TLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGS 175
            .||. ||               :::|..::.:||.|...|.|.|.:.:....:::.:       :
Human   148 NLAL-AT---------------ETNCNFELLHFPRDHSNCSLSFYALSNTAMELEFQ-------A 189

  Fly   176 NVVAVGVDLSEFYMSVEWDI-LEVPAVRNEKFYTCCDEPYLDITFNITMRRK--TLFYTVNIIIP 237
            :||...|.:...|  |.:|: .:||.   ::...|         |.:|:|.|  .|...:.:::|
Human   190 HVVNEIVSVKREY--VVYDLKTQVPP---QQLVPC---------FQVTLRLKNTALKSIIALLVP 240

  Fly   238 CMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVS 302
            ...:....|....||..:.|::...:::|:|..|....:|:.:|.:|...|||..|....::|:.
Human   241 AEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLF 305

  Fly   303 ISICVTVVVLNVHFRSPQTHKMAP 326
            :|...||::..:..|.....|..|
Human   306 LSTIETVLLAGLLARGNLGAKSGP 329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:455710 73/349 (21%)
LGIC_ECD_nAChR_proto_alpha-like 11..229 CDD:349832 46/240 (19%)
Cys-loop 136..150 CDD:349832 4/13 (31%)
ZACNNP_851321.2 LGIC_ECD_ZAC 60..229 CDD:349795 41/206 (20%)
Cys-loop 157..171 CDD:349795 4/13 (31%)
LGIC_TM 231..407 CDD:476813 23/99 (23%)
TM1 helix 235..255 CDD:349850 2/19 (11%)
TM2 helix 263..284 CDD:349850 4/20 (20%)
TM3 helix 295..317 CDD:349850 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 328..360 1/2 (50%)
TM4 helix 365..386 CDD:349850
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.