Protein Alignment nAChRalpha4 and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 201/547 - (36%)
• Similarity: 285/547 - (52%)
• Gaps: 102/547 - (18%)

  Fly    10 PDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLR 74
            |..|||.:.|||.||.|.|||.|.::.|:|...|.|.|:|||:.||||:|||.|:...|.||.||
  Fly    28 PHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLR 92

  Fly    75 WEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEID 139
            |...|||||..|.:..:.:|:||:::||:||..|:.|..|...:...|...:.||.|:||:|:||
  Fly    93 WNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKID 157

  Fly   140 VEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNE 204
            :.:||||:|.|.:|||||||||.::||....|..|        |||:|..:.||.:|.:|..:|.
  Fly   158 ITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG--------DLSDFITNGEWYLLAMPGKKNT 214

  Fly   205 KFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISL 269
            ..|.||.|||:||||.|.:||:||:|..|:|:||:.||.:.:|.|.||.|||||:||.::||:||
  Fly   215 IVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSL 279

  Fly   270 HVFFLLVVEIIPPTS-------------------LV----------VPLLGKYLIFAMILVSISI 305
            .||..||.|.:|.||                   ||          :||||.|....|.:|:.|:
  Fly   280 TVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSV 344

  Fly   306 CVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSAT 370
            .:||||||.|.|:...|:|.||:|.||:.:||..|.:.||........:||
  Fly   345 VLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILL-------------- 395

  Fly   371 NIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMD------IG 429
                  |:.......||..|:|:.||                          |.|:|      |.
  Fly   396 ------SNRMKELELKERSSKSLLAN--------------------------VLDIDDDFRHTIS 428

  Fly   430 PLGMKSPILNNPAFSHSKCLPKIHKSCFC-----------VRFIAEHTKMQEDSTKVKEDWKYVA 483
              |.::.|.::.:|.....:.:.|.:..|           ::||....:..:|..::..|||:.|
  Fly   429 --GSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAA 491

  Fly   484 MVLDRLFLWIFTLAVVVGTAGIILQAP 510
            ||:||..|.:|||..::.|..::|.||
  Fly   492 MVVDRFCLIVFTLFTIIATVTVLLSAP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	198/540 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	102/217 (47%)
		Cys-loop	136..150	CDD:349832	8/13 (62%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	199/544 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	87/188 (46%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)