Protein Alignment nAChRalpha4 and nAChRbeta3

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Alignment Length: 513
• Identity: 120/513 - (23%)
• Similarity: 213/513 - (41%)
• Gaps: 126/513 - (24%)

  Fly     2 VHGAVA----GNPDAK---RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMT 59
            |.||.|    .|.:.|   ||:..|.:||:..|:||...|.. .|.:::.:: .||::..|..:|
  Fly    34 VPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPT-NVSLEMVVT-YIDIDELNGKLT 96

  Fly    60 TNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLV 124
            |:.|:...|.|.:..|:|.:|..:..:.:.|..:|.|.|.|:|..:|.  :...|:.|:..:|..
  Fly    97 THCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG--LMAETQVTLSHDGHF 159

  Fly   125 EWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYM 189
            .|.|||:|.:.||:::..:|.|:|:|.||.|||   |.||.|......:|.:     :|..:...
  Fly   160 RWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTARGES-----LDHDDLVQ 216

  Fly   190 SVEWDILEVPA-VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPS 253
            |.||:|::..| ..::.:|     .|::.|  :|.:|::..||..|..|...|..|.:..|:||.
  Fly   217 SPEWEIVDSRAHFVSQDYY-----GYMEYT--LTAQRRSSMYTAVIYTPASCIVILALSAFWLPP 274

  Fly   254 D-SGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFR 317
            . .|||:.::..::|.:..|.:...:::|..|...||:..:...:::.:|:|..|.|:||   :.
  Fly   275 HMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL---YL 336

  Fly   318 SPQTHK--MAPWVKRVFIDFLPAFLFIK--RPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSS 378
            :...||  :...::::....|..:|.:.  ..|...:..|....|.|    ||..|
  Fly   337 ATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEH----PYEEA--------- 388

  Fly   379 GYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAF 443
                                                   ||      .:..|||:
  Fly   389 ---------------------------------------DE------QESSPLGI---------- 398

  Fly   444 SHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKE-DWKYVAMVLDRLFLWIFTLAVVV 500
                                .||::  ...|..: ||..:|..:||:....|:||.::
  Fly   399 --------------------NHTEV--PGAKANQFDWALLATAVDRISFVSFSLAFLI 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	120/513 (23%)
		Neur_chan_LBD	12..227	CDD:280998	64/218 (29%)
		Neur_chan_memb	234..505	CDD:280999	49/273 (18%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	117/508 (23%)
		Neur_chan_LBD	52..247	CDD:280998	62/213 (29%)
		Neur_chan_memb	255..434	CDD:280999	49/271 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840