DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha4 and nAChRalpha7

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	217/551 - (39%)
Similarity:	317/551 - (57%)	Gaps:	78/551 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVHG--------AVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQI 57
            :|:|        |.|..|..|||...||.|||.|.|||||.:|.|::...|.|.|:|||:.|||:
  Fly    42 LVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQL 106

  Fly    58 MTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEG 122
            :.||:|::..|.|..|||...|:|||..|.:|...:|:||:::||:||..|:.|.||...:.:.|
  Fly   107 LITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNG 171

  Fly   123 LVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEF 187
            ...:.||.|:||:|:||:.:||||:|.|.:||||||||||::||:..||        .|.|:|.|
  Fly   172 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDE--------AGGDISSF 228

  Fly   188 YMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLP 252
            ..:.|||:|.||..|||.:|.||.|||:||||.|.:|||||:|..|:|:||:.|:.:.:|.|.||
  Fly   229 ITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLP 293

  Fly   253 SDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFR 317
            .|||||::|.::||:||.||..:|.|.:|.||..|||||.|....|.:|:.|:..|:::||.|.|
  Fly   294 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 358

  Fly   318 SPQTHKMAPWVKRVFIDFLPAFLFIKRP-TYNFETSKLLLKDTHACFYPYYSATNIDRLVSSG-- 379
            :|.||:|:.|::.:|:.:||..|.::|| ...:|           |..|..|:::    .:||
  Fly   359 NPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYE-----------CPPPPSSSSS----SASGEK 408

  Fly   380 ---YNNSLPKEDLSQSITAN-----GPFGGSCQVHGPVPPLTHCSSDEIAAVP-----------D 425
               ..|...||..|:|:.||     ..|  .|. |       .|:|..:...|           |
  Fly   409 KQQIQNVELKERSSKSLLANVLDIDDDF--RCN-H-------RCASATLPHQPTYYRTMYRQGDD 463

  Fly   426 MDIGPLGMKSPILN---NPAFSHSKCLPK--------IHKSCFCVRFIAEHTKMQEDSTKVKEDW 479
            ..:||:|...|:::   :.|.||: ||..        |.|.   :|:|.|..|.:::::.:..||
  Fly   464 GSVGPVGPAGPVVDGRLHEAISHT-CLTSSAEYELALILKE---LRWITEQLKKEDETSDITRDW 524

  Fly   480 KYVAMVLDRLFLWIFTLAVVVGTAGIILQAP 510
            |:.|||:|||.|.||||..::.|..::..||
  Fly   525 KFAAMVVDRLCLIIFTLFTIIATLAVLFSAP 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	215/544 (40%)
		Neur_chan_LBD	12..227	CDD:280998	105/214 (49%)
		Neur_chan_memb	234..505	CDD:280999	100/303 (33%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	210/525 (40%)
		Neur_chan_LBD	61..268	CDD:280998	105/214 (49%)
		Neur_chan_memb	275..552	CDD:280999	100/305 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940