Protein Alignment nAChRalpha4 and nAChRalpha7

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 551
• Identity: 217/551 - (39%)
• Similarity: 317/551 - (57%)
• Gaps: 78/551 - (14%)

  Fly     1 MVHG--------AVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQI 57
            :|:|        |.|..|..|||...||.|||.|.|||||.:|.|::...|.|.|:|||:.|||:
  Fly    42 LVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQL 106

  Fly    58 MTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEG 122
            :.||:|::..|.|..|||...|:|||..|.:|...:|:||:::||:||..|:.|.||...:.:.|
  Fly   107 LITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNG 171

  Fly   123 LVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEF 187
            ...:.||.|:||:|:||:.:||||:|.|.:||||||||||::||:..||        .|.|:|.|
  Fly   172 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDE--------AGGDISSF 228

  Fly   188 YMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLP 252
            ..:.|||:|.||..|||.:|.||.|||:||||.|.:|||||:|..|:|:||:.|:.:.:|.|.||
  Fly   229 ITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLP 293

  Fly   253 SDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFR 317
            .|||||::|.::||:||.||..:|.|.:|.||..|||||.|....|.:|:.|:..|:::||.|.|
  Fly   294 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 358

  Fly   318 SPQTHKMAPWVKRVFIDFLPAFLFIKRP-TYNFETSKLLLKDTHACFYPYYSATNIDRLVSSG-- 379
            :|.||:|:.|::.:|:.:||..|.::|| ...:|           |..|..|:::    .:||
  Fly   359 NPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYE-----------CPPPPSSSSS----SASGEK 408

  Fly   380 ---YNNSLPKEDLSQSITAN-----GPFGGSCQVHGPVPPLTHCSSDEIAAVP-----------D 425
               ..|...||..|:|:.||     ..|  .|. |       .|:|..:...|           |
  Fly   409 KQQIQNVELKERSSKSLLANVLDIDDDF--RCN-H-------RCASATLPHQPTYYRTMYRQGDD 463

  Fly   426 MDIGPLGMKSPILN---NPAFSHSKCLPK--------IHKSCFCVRFIAEHTKMQEDSTKVKEDW 479
            ..:||:|...|:::   :.|.||: ||..        |.|.   :|:|.|..|.:::::.:..||
  Fly   464 GSVGPVGPAGPVVDGRLHEAISHT-CLTSSAEYELALILKE---LRWITEQLKKEDETSDITRDW 524

  Fly   480 KYVAMVLDRLFLWIFTLAVVVGTAGIILQAP 510
            |:.|||:|||.|.||||..::.|..::..||
  Fly   525 KFAAMVVDRLCLIIFTLFTIIATLAVLFSAP 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	215/544 (40%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	107/217 (49%)
		Cys-loop	136..150	CDD:349832	8/13 (62%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	210/525 (40%)