DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha4 and nAChRalpha3

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_001285015.1 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster


Alignment Length:770 Identity:378/770 - (49%)
Similarity:433/770 - (56%) Gaps:245/770 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 NPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 73
            ||||||||||||||||||||||||.||.|.|.|||||||||||||||||||||||||||||||||
  Fly    23 NPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 87

  Fly    74 RWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEI 138
            :|||||||||.|||||||||||||||||||||||||||||||||:...|.|||:|||||||||||
  Fly    88 KWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEI 152

  Fly   139 DVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRN 203
            |||||||||||||:||||||||||:|||||:||..|:|||.|||||||||.||||||||||||||
  Fly   153 DVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRN 217

  Fly   204 EKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILIS 268
            ||||||||||||||||||||||||||||||:|||||||||||:|.|||||||||||:||||||:|
  Fly   218 EKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLS 282

  Fly   269 LHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFI 333
            |.|||||:.|||||||||||||||:::|.|||.:.||||||:|||:||||||||.|||||:.|||
  Fly   283 LTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFI 347

  Fly   334 DFLPAFLFIKRPTY----NFETSKLLLKDT-----------------------HA---------- 361
            :.||.||.::||.|    ..::|:.|:..|                       |:          
  Fly   348 NQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSP 412

  Fly   362 --------------C-----------------FYPYYSAT------NIDRLVSSGYNNSLPKED- 388
                          |                 .||...:|      ....|:.:.|:|...:.. 
  Fly   413 HLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGG 477

  Fly   389 --LSQSIT-----------------------ANGPFGG--------------SCQVH-GPVPPLT 413
              |...:|                       .||.:||              ||..: .|:|...
  Fly   478 SLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHA 542

  Fly   414 H-------------------------------------CSSDEIAAVPDMDIGPLGMKSPILNNP 441
            |                                     |.|..|.....|..|.....|.:|::.
  Fly   543 HQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQ 607

  Fly   442 AFSHSK----------------------------------------------------------- 447
            ...|.:                                                           
  Fly   608 QLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPP 672

  Fly   448 ------------------C------------LPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYV 482
                              |            .|::||:...|.:||:.|:.:|:||:||||||||
  Fly   673 AGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYV 737

  Fly   483 AMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDFSGTSAGRCRP 537
            |||||||||||||:||||||||||||||||||.|:||    |:..|..::...:|
  Fly   738 AMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMPI----DIKLSEIASTTAKP 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 361/736 (49%)
Neur_chan_LBD 12..227 CDD:280998 194/214 (91%)
Neur_chan_memb 234..505 CDD:280999 156/511 (31%)
nAChRalpha3NP_001285015.1 Neur_chan_LBD 26..241 CDD:280998 194/214 (91%)
Neur_chan_memb 248..>359 CDD:280999 84/110 (76%)
Neur_chan_memb <683..760 CDD:280999 39/76 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45468864
Domainoid 1 1.000 250 1.000 Domainoid score I2065
eggNOG 1 0.900 - - E1_KOG3645
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 473 1.000 Inparanoid score I1461
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm6399
orthoMCL 1 0.900 - - OOG6_101158
Panther 1 1.100 - - P PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X294
1110.800

Return to query results.
Submit another query.