Protein Alignment nAChRalpha4 and chrna1

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_571520.1
• Gene: chrna1 / 30725
• ZFINID: ZDB-GENE-980526-137
• Length: 456
• Species: Danio rerio
• Alignment Length: 513
• Identity: 199/513 - (38%)
• Similarity: 282/513 - (54%)
• Gaps: 90/513 - (17%)

  Fly     2 VHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQ 66
            ::|....:.|..||...|.:.|||:||||.:..|.:.|.:.|:|.|||.|:..|||:|:|:.::|
Zfish    14 LYGPAVCSEDETRLVKTLFTGYNKVVRPVSHFKDPVVVTVGLQLIQLISVDEVNQIVTSNVRLKQ 78

  Fly    67 SWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAI 131
            .|.|..|:|.|.:|||:..:.:||..:|:||:||||||||:|.:...||..:...|::.|.||||
Zfish    79 QWKDVHLQWNPDDYGGIRKIRIPSTDLWKPDLVLYNNADGDFAIVHETKVLLEHTGMITWTPPAI 143

  Fly   132 YKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVG-----VDLSEFYMSV 191
            :||.|||.|.:||||.|.|.:|.|:|||||              |:|.:.     .|||.|..|.
Zfish   144 FKSYCEIVVLHFPFDLQNCSMKLGTWTYDG--------------NLVIINPDSDRPDLSNFMESG 194

  Fly   192 EWDILEVPAVRNEKFYTCC-DEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS 255
            ||.:.:..:.::..:|.|| |.||||||::..:.|..|::.||:|||||..||||.|.||||:||
Zfish   195 EWVMKDYRSWKHWVYYACCPDTPYLDITYHFLLLRLPLYFIVNVIIPCMLFSFLTGLVFYLPTDS 259

  Fly   256 GEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQ 320
            |||:|||||:|:||.||.|::||:||.||..|||:|||::|.||.|..||.:||:|:|.|.|||.
Zfish   260 GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVIASIIITVIVINTHHRSPS 324

  Fly   321 THKMAPWVKRVFIDFLPAFLF---IKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNN 382
            ||.|..||:::|||.:|..:|   :|||:...:..:|         :|
Zfish   325 THIMPAWVRKIFIDTIPNMMFFSTMKRPSQERQEKRL---------FP----------------- 363

  Fly   383 SLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSK 447
                .|...|..:..|...|...|                            |||..|
Zfish   364 ----ADFDISDISGKPMPASVTYH----------------------------SPITKN------- 389

  Fly   448 CLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGI 505
              |.:..:...|::||:..|..|:|....|:||:||||||.:.|.:|....::||.|:
Zfish   390 --PDVRSAIEGVKYIADTMKSDEESNNAAEEWKFVAMVLDHILLCVFMAVCIIGTLGV 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	198/511 (39%)
		Neur_chan_LBD	12..227	CDD:280998	93/220 (42%)
		Neur_chan_memb	234..505	CDD:280999	100/273 (37%)
chrna1	NP_571520.1	LIC	21..447	CDD:273305	198/506 (39%)
		Neur_chan_LBD	24..231	CDD:280998	93/220 (42%)
		Neur_chan_memb	238..446	CDD:280999	101/275 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920