DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha4 and Chrne

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_017452660.1	Gene:	Chrne / 29422	RGDID:	2353	Length:	547	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	165/517 - (31%)
Similarity:	265/517 - (51%)	Gaps:	50/517 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSW 68
            |...|..:...||..|..||:...|||....|.:.:.:|:.|:.||.:|.|.:.:||::|:...|
  Rat    69 GRSQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEW 133

  Fly    69 YDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYK 133
            .||:|.:...::.||.:|.|||:|:|.|:|||.||.||.|.|.......:|..|.|.|.|||||:
  Rat   134 QDYRLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYR 198

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEV 198
            |:|.::|.|||||.|.|.|.|.|.||:..:|:.....:..|:.:..:.:|.:.|..:.||.|...
  Rat   199 STCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNAINKIDIDTAAFTENGEWAIDYC 263

  Fly   199 PA-VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS-GEKVTL 261
            |. :|:.:..:..|....|:.:.:.:|||.|||.:|||:||:.||.|.:|.::||:.: |:|.|:
  Rat   264 PGMIRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTV 328

  Fly   262 SISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAP 326
            ||::|::..||..|:.:.||.|||.|||||:||||.|::.::.:...|:||||..|:|.||..:|
  Rat   329 SINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSP 393

  Fly   327 WVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQ 391
            .::::.::.||..|.:..|.          :|..|. .|...|:::..|:.:  ...:.|:..|:
  Rat   394 RLRQILLELLPRLLGLSPPP----------EDPGAA-SPARRASSVGILLRA--EELILKKPRSE 445

  Fly   392 SITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSC 456
            .:     |.|....||.......|.:...||                           |::....
  Rat   446 LV-----FEGQRHRHGTWTAAALCQNLSAAA---------------------------PEVRCCV 478

  Fly   457 FCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIP 518
            ..|.|:||.|:.||.:.:...||..:...||.:..|...:...||:..|.|..   |.:::|
  Rat   479 DAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGG---YFNQVP 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	161/502 (32%)
		Neur_chan_LBD	12..227	CDD:280998	77/215 (36%)
		Neur_chan_memb	234..505	CDD:280999	77/271 (28%)
Chrne	XP_017452660.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810