Protein Alignment nAChRalpha4 and GABRG2

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 83/400 - (20%)
• Similarity: 162/400 - (40%)
• Gaps: 71/400 - (17%)

  Fly    11 DAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRW 75
            |...:.::||..|:..:||.:.....| :...:.::.:..||..|...|.:::..|:|||.:|::
Human    65 DVTVILNNLLEGYDNKLRPDIGVKPTL-IHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF 128

  Fly    76 EPKEYGGVHMLHVPSD---HIWRPDIVLYNN--ADGNFEVTLATKATIYSEGLVEWKPPAIYKSS 135
            .    ..:.:|.:.|:   .||.||....|:  ||.::..|......|:::|.|.:.......:.
Human   129 N----STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

  Fly   136 CEIDVEYFPFDEQTCVLKFGSWTYD-----------GFKVDLRHMDEQQGSNVVAVGVDLSEFY- 188
            |::.:..||.||.:|.|:|.||:..           .....||.........:.:....:|:.|
Human   190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYP 254

  Fly   189 ---MSVEW--DILEVPAVRNEKFY----------------TCCDEPYLDITFNITMRRKTLFYTV 232
               :..:|  ..:||...|:.:.|                |..|...:.:.|:::  |:..::|:
Human   255 REEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS--RRMGYFTI 317

  Fly   233 NIIIPCMGISFLTVLTFYLPSDS-GEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIF 296
            ...|||..|..|:.::|::..|: ..:.:|.|:.::::.....:..:.:|..|.|.
Human   318 QTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVT--------- 373

  Fly   297 AMILVSISICVTVVVL------NVHF----RSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFET 351
            ||.|. :|:|...|..      .:|:    |.|...|    .|:.....|..|.| |.||.:...
Human   374 AMDLF-VSVCFIFVFSALVEYGTLHYFVSNRKPSKDK----DKKKKNPLLRMFSF-KAPTIDIRP 432

  Fly   352 SKLLLKDTHA 361
            ....::..:|
Human   433 RSATIQMNNA 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	82/399 (21%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	52/255 (20%)
		Cys-loop	136..150	CDD:349832	5/13 (38%)
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	81/395 (21%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	45/227 (20%)
		Cys-loop	190..204	CDD:349801	5/13 (38%)