DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha4 and Chrna7

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_036964.3	Gene:	Chrna7 / 25302	RGDID:	2348	Length:	502	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	208/545 - (38%)
Similarity:	302/545 - (55%)	Gaps:	75/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVE 65
            ::|.::.|. ..:|||.:|:.|||.|.|||.|.:..|.|...|.|.|::||:.|||::|||:|::
  Rat    16 LLHVSLQGE-FQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQ 79

  Fly    66 QSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPA 130
            .||.|:.|:|...||.||..:..|...||:|||:|||:||..|:.|..|...:.:.|..::.||.
  Rat    80 MSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPG 144

  Fly   131 IYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDI 195
            |:||||.|||.:||||.|.|.||||||:|.|:.:||: |.|          .|:|.:..:.|||:
  Rat   145 IFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQ-MQE----------ADISSYIPNGEWDL 198

  Fly   196 LEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVT 260
            :.:|..||||||.||.|||.|:|:.:||||:||:|.:|::|||:.||.|.:|.|.||:|||||::
  Rat   199 MGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKIS 263

  Fly   261 LSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMA 325
            |.|::|:||.||.|||.||:|.||..|||:.:|....||:|.:|:.|||:||..|...|...||.
  Rat   264 LGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMP 328

  Fly   326 PWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLS 390
            .|.:.:.:::...||.:|||..:        |...||.:             .....||...:||
  Rat   329 KWTRIILLNWCAWFLRMKRPGED--------KVRPACQH-------------KPRRCSLASVELS 372

  Fly   391 QSI---TANGP--FGGSCQVHGPVPPLTHCSSDEIAAVPDMDI--GPLGMKSPILNNPAFSHSKC 448
            ...   |:||.  :.|...:.|     .||     |..||..:  |.|.. ||       :|.:.
  Rat   373 AGAGPPTSNGNLLYIGFRGLEG-----MHC-----APTPDSGVVCGRLAC-SP-------THDEH 419

  Fly   449 L----------PKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTA 503
            |          |.:.|....||:||...:.|::|..:..:||:.|.|:|||.|..|::..::.|.
  Rat   420 LMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTI 484

  Fly   504 GIILQAPTLYDDRIPIIEQKDLDFS 528
            ||::.||.       .:|....||:
  Rat   485 GILMSAPN-------FVEAVSKDFA 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	201/520 (39%)
		Neur_chan_LBD	12..227	CDD:280998	101/214 (47%)
		Neur_chan_memb	234..505	CDD:280999	94/287 (33%)
Chrna7	NP_036964.3	LIC	4..490	CDD:273305	203/524 (39%)
		Neur_chan_LBD	26..230	CDD:280998	101/214 (47%)
		Neur_chan_memb	237..486	CDD:280999	94/287 (33%)
		Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000250\|UniProtKB:P49582	260..267		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910