DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and Chrnb1

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_001382047.1 Gene:Chrnb1 / 24261 RGDID:2349 Length:504 Species:Rattus norvegicus


Alignment Length:522 Identity:184/522 - (35%)
Similarity:273/522 - (52%) Gaps:71/522 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 GNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDV---NLKNQIMTTNLWVEQSWY 69
            |:....:|...|.|:|:..|||.....|.:.|.|.|.|:|||.:   |.|::.|:|.::::..|.
  Rat    23 GSEAEGQLLKKLFSDYDSSVRPAQEVGDRVGVSIGLTLAQLISLVRENEKDEEMSTKVYLDLEWT 87

  Fly    70 DYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKS 134
            ||:|.|:|.|:.|:..|.|.::.:|.||:||.||.||||:|.|.....:..||.|.|:||.:|:|
  Rat    88 DYRLSWDPAEHDGIESLRVTAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRS 152

  Fly   135 SCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVP 199
            ||.|.|.|||||.|.|.:.|.|::||..:|.|:...:..|.....:.:....|..:.:|:|:..|
  Rat   153 SCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGPDPDGQERQEIYIHEGTFIENGQWEIIHKP 217

  Fly   200 A--------VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSG 256
            :        .|..|     :....::.|.:.:|||.|||.||:|.||:.|:.|.:..||||.|:|
  Rat   218 SRLIHLPGDRRGGK-----EGHREEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAG 277

  Fly   257 EKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQT 321
            ||:.|||..|::|.||.||:.:.:|.|||.||::.|||:|.||||:.|:.::|||||:|.|||.|
  Rat   278 EKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMILVTFSVILSVVVLNLHHRSPHT 342

  Fly   322 HKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSL-- 384
            |:|..||:::||..||.:|.:|||    :..:..|.:.|..|.|           .||:....  
  Rat   343 HQMPFWVRQIFIHKLPPYLGLKRP----KPERDQLPEPHHSFSP-----------RSGWGRGTDE 392

  Fly   385 ------PKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAF 443
                  |.:.|...:....|       ..|.|.|......     |...:|              
  Rat   393 YFIRKPPCDFLFPKLNRFQP-------ESPAPDLRRFIDG-----PPRAVG-------------- 431

  Fly   444 SHSKCLP-KIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIIL 507
                 || ::.:....:.::|...:.|||...:||||::||||:||||||.|.:...|||..|.|
  Rat   432 -----LPQELREVISSISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFL 491

  Fly   508 QA 509
            .|
  Rat   492 DA 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 181/516 (35%)
Neur_chan_LBD 12..227 CDD:280998 77/225 (34%)
Neur_chan_memb 234..505 CDD:280999 97/279 (35%)
Chrnb1NP_001382047.1 LGIC_ECD_nAChR_B1 27..248 CDD:349825 77/225 (34%)
Neur_chan_memb 255..490 CDD:397193 97/280 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 365..384 6/33 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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