Protein Alignment nAChRalpha4 and GABRR3

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 74/361 - (20%)
• Similarity: 142/361 - (39%)
• Gaps: 73/361 - (20%)

  Fly    16 YDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            |:.||  .:.:..:||....:.| .|.|.:.:..:..::..|...|...::...|.|.:|.:...
Human    61 YEQLLHIEDNDFAMRPGFGGSPV-PVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPST 124

  Fly    79 EYGGVHMLHVPSDHIWRPD------------------IVLYNNADGNFEVTLATKATIYSEGLVE 125
            ....:...|..:..||.||                  |:|..:.|||  |.|:.:.|:
Human   125 ANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGN--VLLSLRITV------- 180

  Fly   126 WKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTY--DGFKVDLRHMDEQQGSNVVAVGVDLSEFY 188
                   .:.|.:|...||.|.|.|.|:..|:.|  |...:..:|.::...:.   ..:.||:|:
Human   181 -------SAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTE---EHMSLSQFF 235

  Fly   189 MSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYL-- 251
                  |.:..|.....||:.... |..:..|..:||...|:.:....|.:.:..|:.::|::
Human   236 ------IEDFSASSGLAFYSSTGW-YNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDR 293

  Fly   252 ---PSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISIC------- 306
               |:    :|:|.|:.::::......|...:|..| .:..:..||..:.:.|.:|:.
Human   294 RAVPA----RVSLGITTVLTMSTIITAVSASMPQVS-YLKAVDVYLWVSSLFVFLSVIEYAAVNY 353

  Fly   307 VTVVVLNVHFRSPQTHKMAPWVKRVF-IDFLPAFLF 341
            :|.|.....|:  :|.|    :.|:: ||.:.|..|
Human   354 LTTVEERKQFK--KTGK----ISRMYNIDAVQAMAF 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	74/361 (20%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	49/234 (21%)
		Cys-loop	136..150	CDD:349832	6/13 (46%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:455710	74/361 (20%)
		LGIC_ECD_GABAAR_rho	82..267	CDD:349806	44/211 (21%)
		Cys-loop	184..198	CDD:349806	6/13 (46%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:P50573	347..448		10/43 (23%)