Protein Alignment nAChRalpha4 and acr-19

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001129756.1
• Gene: acr-19 / 191605
• WormBaseID: WBGene00000058
• Length: 560
• Species: Caenorhabditis elegans
• Alignment Length: 555
• Identity: 180/555 - (32%)
• Similarity: 282/555 - (50%)
• Gaps: 81/555 - (14%)

  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            :|||..|..|||||.|||.|.::.:.|.:.:...|::|::.|:|||.:|:|:..||.|:.|.|:|
 Worm    32 RRLYAKLAENYNKLARPVRNESEAVVVLLGMDYQQILDIDEKHQIMNSNVWLRMSWTDHYLTWDP 96

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEY 142
            .|:|.:..:.:|.::||:||::|||:.|..|:.|....|.:...|.|.|.||||.:|||.||:.|
 Worm    97 SEFGNIKEVRLPINNIWKPDVLLYNSVDQQFDSTWPVNAVVLYTGNVTWIPPAIIRSSCAIDIAY 161

  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFY 207
            ||||.|.|.:|||||||.||..||           :...:..:.:..:.||::|.:.:.|:..||
 Worm   162 FPFDTQHCTMKFGSWTYSGFFTDL-----------INTTISPATYKPNGEWELLGLTSQRSIFFY 215

  Fly   208 TCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVF 272
            .||.|||.|:||.:::||:||:|..|:::|||.||.|.:|:|.||:|.|||:.|.::|.:||.||
 Worm   216 ECCPEPYYDVTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFTLPADCGEKLNLGVTIFMSLCVF 280

  Fly   273 FLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHK-MAPWVKRVFIDFL 336
            .::|.|.:|.||..:||:..|....|..|..|:..||:.||.|.|||:.:| |..::|.:.:.:|
 Worm   281 MIMVAEAMPQTSDALPLIQIYFSCIMFQVGASVVATVIALNFHHRSPEQYKPMNKFLKTLLLGWL 345

  Fly   337 PAFLFIKRPT----------YNFETSK-----LLLKDTHACFYPY---YSATNIDRLVSSGYNNS 383
            |..|.::||.          |..:..|     |:..:.|....|.   :||  :|:.|....:..
 Worm   346 PTLLGMERPDVLELSVHGAHYASDNKKKQRQYLIEVERHILTRPNGNGHSA--VDKAVHLDLSTG 408

  Fly   384 LPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDI-GPLG----------MKSPI 437
            .|..|..:|              .|.|..|..|...:..:|...: |.|.          :..|:
 Worm   409 NPHSDAKKS--------------SPSPKRTSASIMGMTGLPTTQMNGALDSSINKYTCTKVTRPL 459

  Fly   438 LNNPAFSHSKCLPKI------------------------HKSCFCVRFIAEHTKMQEDSTKVKED 478
            .|..|..:.|..|:|                        |.....:|.|:...:.:|....::.|
 Worm   460 ENGSATINHKSSPQINPINNNNIYKCANNQKTQFEDRHFHHILNELRVISARVRKEEAMHALQAD 524

  Fly   479 WKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLY 513
            |.:.:.|:||:....|:..:.:.||.|...||.|:
 Worm   525 WMFASRVVDRVCFLAFSAFLFMCTAIISYNAPHLF 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	176/545 (32%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	89/215 (41%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
acr-19	NP_001129756.1	LIC	31..548	CDD:455710	174/542 (32%)
		LGIC_ECD_nAChR	56..234	CDD:349798	74/188 (39%)
		Cys-loop	155..169	CDD:349798	9/13 (69%)