Protein Alignment nAChRalpha4 and acr-19

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001129756.1
• Gene: acr-19 / 191605
• WormBaseID: WBGene00000058
• Length: 560
• Species: Caenorhabditis elegans
• Alignment Length: 555
• Identity: 180/555 - (32%)
• Similarity: 282/555 - (50%)
• Gaps: 81/555 - (14%)

  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            :|||..|..|||||.|||.|.::.:.|.:.:...|::|::.|:|||.:|:|:..||.|:.|.|:|
 Worm    32 RRLYAKLAENYNKLARPVRNESEAVVVLLGMDYQQILDIDEKHQIMNSNVWLRMSWTDHYLTWDP 96

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEY 142
            .|:|.:..:.:|.::||:||::|||:.|..|:.|....|.:...|.|.|.||||.:|||.||:.|
 Worm    97 SEFGNIKEVRLPINNIWKPDVLLYNSVDQQFDSTWPVNAVVLYTGNVTWIPPAIIRSSCAIDIAY 161

  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFY 207
            ||||.|.|.:|||||||.||..||           :...:..:.:..:.||::|.:.:.|:..||
 Worm   162 FPFDTQHCTMKFGSWTYSGFFTDL-----------INTTISPATYKPNGEWELLGLTSQRSIFFY 215

  Fly   208 TCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVF 272
            .||.|||.|:||.:::||:||:|..|:::|||.||.|.:|:|.||:|.|||:.|.::|.:||.||
 Worm   216 ECCPEPYYDVTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFTLPADCGEKLNLGVTIFMSLCVF 280

  Fly   273 FLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHK-MAPWVKRVFIDFL 336
            .::|.|.:|.||..:||:..|....|..|..|:..||:.||.|.|||:.:| |..::|.:.:.:|
 Worm   281 MIMVAEAMPQTSDALPLIQIYFSCIMFQVGASVVATVIALNFHHRSPEQYKPMNKFLKTLLLGWL 345

  Fly   337 PAFLFIKRPT----------YNFETSK-----LLLKDTHACFYPY---YSATNIDRLVSSGYNNS 383
            |..|.::||.          |..:..|     |:..:.|....|.   :||  :|:.|....:..
 Worm   346 PTLLGMERPDVLELSVHGAHYASDNKKKQRQYLIEVERHILTRPNGNGHSA--VDKAVHLDLSTG 408

  Fly   384 LPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDI-GPLG----------MKSPI 437
            .|..|..:|              .|.|..|..|...:..:|...: |.|.          :..|:
 Worm   409 NPHSDAKKS--------------SPSPKRTSASIMGMTGLPTTQMNGALDSSINKYTCTKVTRPL 459

  Fly   438 LNNPAFSHSKCLPKI------------------------HKSCFCVRFIAEHTKMQEDSTKVKED 478
            .|..|..:.|..|:|                        |.....:|.|:...:.:|....::.|
 Worm   460 ENGSATINHKSSPQINPINNNNIYKCANNQKTQFEDRHFHHILNELRVISARVRKEEAMHALQAD 524

  Fly   479 WKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLY 513
            |.:.:.|:||:....|:..:.:.||.|...||.|:
 Worm   525 WMFASRVVDRVCFLAFSAFLFMCTAIISYNAPHLF 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	176/545 (32%)
		Neur_chan_LBD	12..227	CDD:280998	88/213 (41%)
		Neur_chan_memb	234..505	CDD:280999	84/324 (26%)
acr-19	NP_001129756.1	LIC	31..548	CDD:273305	174/542 (32%)
		Neur_chan_LBD	31..235	CDD:280998	88/213 (41%)
		Neur_chan_memb	242..>354	CDD:280999	45/111 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910