Protein Alignment nAChRalpha4 and acr-18

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_506868.2
• Gene: acr-18 / 191604
• WormBaseID: WBGene00000057
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 140/524 - (26%)
• Similarity: 258/524 - (49%)
• Gaps: 70/524 - (13%)

  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            :.||:.|..:|.|.:|||.|.::.|||.||..|.|::.|:.::||:....|:|..|.|..|.|:|
 Worm    31 RNLYEHLFLDYVKEIRPVRNESESLKVEIKFWLKQILKVDERDQIVNIYCWLELYWIDETLTWDP 95

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVT-LATKATIYSEGLVEWKPPAIYKSSCEIDVE 141
            |::|.:..:|||:..||:||:::||||:.|.|.. :.|.|.:.:.|.|......|...||.::::
 Worm    96 KKFGNLSRIHVPAHKIWKPDVLVYNNANMNVEENEMETNAIVDNTGRVMLFRSMITDISCNLNLQ 160

  Fly   142 YFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYM-SVEWDILEVPAVRNEK 205
            .||||:|.|.:.|.||:.||.|:||....:          .|..|.|: :.||.:.:......:|
 Worm   161 QFPFDQQICFVTFASWSMDGSKLDLSATPK----------TDNLELYIRNTEWGLTDFRVKIYQK 215

  Fly   206 FYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLP----SDSGEKVTLSISIL 266
            .|.||..|:.|:|:.:.:||...:|..:::||...|:.:|::.|:.|    .::.|||:|.::.|
 Worm   216 IYDCCPHPFPDVTYFMVLRRSPSYYIFSLVIPSAFITVVTIVGFFTPHSTTGENTEKVSLGVTAL 280

  Fly   267 ISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRV 331
            :|:.:..::|.:.:|.||.|:||:|||.|..:.|:.::...|.:.|:...|.....::.|.|:..
 Worm   281 LSMAIIMMMVSDEVPATSEVIPLIGKYYIGLIFLIFMAAFTTTLTLSYQMRGNSGQEVDPRVRDF 345

  Fly   332 FIDFLPAFLFIKRP----TYNFETSKLLLKDTH--ACFYPYYSATNIDRLVSSGYNNSLPKEDLS 390
            |.     :.....|    .::|:..|.||:..|  ..|:....|.::     :||:..
 Worm   346 FF-----YQIAANPCISWAFSFQLPKKLLRSDHRKQSFFFTNGAAHV-----NGYSKG------- 393

  Fly   391 QSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKS 455
                         .:|...||......:||.       |...:||.:::..:.:.|..|.   .|
 Worm   394 -------------ALHPNTPPAHIVKMEEIT-------GGGSVKSFVMSQESAATSTLLT---SS 435

  Fly   456 CFCVRFIAEHTK----MQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQA---PTLY 513
            ...::.:.:..|    .:.:..::|.:|:.|..::||..::.:.| :.:..|.::|.:   |.:.
 Worm   436 LMKIKVVLDDMKASIHAERELKRIKFEWQQVTRLIDRCIMFSYIL-ITIAFAMVMLASRDPPIVL 499

  Fly   514 DDRI 517
            :|.|
 Worm   500 NDLI 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	136/507 (27%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	76/217 (35%)
		Cys-loop	136..150	CDD:349832	6/13 (46%)
acr-18	NP_506868.2	LGIC_ECD_nAChR	55..235	CDD:349798	65/189 (34%)
		Cys-loop	155..169	CDD:349798	6/13 (46%)
		LGIC_TM_cation	238..>327	CDD:349853	26/88 (30%)
		TM1 helix	238..262	CDD:349853	6/23 (26%)
		Neur_chan_memb	244..486	CDD:460753	58/282 (21%)
		TM2 helix	274..295	CDD:349853	4/20 (20%)
		TM3 helix	306..327	CDD:349853	5/20 (25%)