DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and acr-18

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_506868.2 Gene:acr-18 / 191604 WormBaseID:WBGene00000057 Length:510 Species:Caenorhabditis elegans


Alignment Length:524 Identity:140/524 - (26%)
Similarity:258/524 - (49%) Gaps:70/524 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            :.||:.|..:|.|.:|||.|.::.|||.||..|.|::.|:.::||:....|:|..|.|..|.|:|
 Worm    31 RNLYEHLFLDYVKEIRPVRNESESLKVEIKFWLKQILKVDERDQIVNIYCWLELYWIDETLTWDP 95

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVT-LATKATIYSEGLVEWKPPAIYKSSCEIDVE 141
            |::|.:..:|||:..||:||:::||||:.|.|.. :.|.|.:.:.|.|......|...||.::::
 Worm    96 KKFGNLSRIHVPAHKIWKPDVLVYNNANMNVEENEMETNAIVDNTGRVMLFRSMITDISCNLNLQ 160

  Fly   142 YFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYM-SVEWDILEVPAVRNEK 205
            .||||:|.|.:.|.||:.||.|:||....:          .|..|.|: :.||.:.:......:|
 Worm   161 QFPFDQQICFVTFASWSMDGSKLDLSATPK----------TDNLELYIRNTEWGLTDFRVKIYQK 215

  Fly   206 FYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLP----SDSGEKVTLSISIL 266
            .|.||..|:.|:|:.:.:||...:|..:::||...|:.:|::.|:.|    .::.|||:|.::.|
 Worm   216 IYDCCPHPFPDVTYFMVLRRSPSYYIFSLVIPSAFITVVTIVGFFTPHSTTGENTEKVSLGVTAL 280

  Fly   267 ISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRV 331
            :|:.:..::|.:.:|.||.|:||:|||.|..:.|:.::...|.:.|:...|.....::.|.|:..
 Worm   281 LSMAIIMMMVSDEVPATSEVIPLIGKYYIGLIFLIFMAAFTTTLTLSYQMRGNSGQEVDPRVRDF 345

  Fly   332 FIDFLPAFLFIKRP----TYNFETSKLLLKDTH--ACFYPYYSATNIDRLVSSGYNNSLPKEDLS 390
            |.     :.....|    .::|:..|.||:..|  ..|:....|.::     :||:..       
 Worm   346 FF-----YQIAANPCISWAFSFQLPKKLLRSDHRKQSFFFTNGAAHV-----NGYSKG------- 393

  Fly   391 QSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKS 455
                         .:|...||......:||.       |...:||.:::..:.:.|..|.   .|
 Worm   394 -------------ALHPNTPPAHIVKMEEIT-------GGGSVKSFVMSQESAATSTLLT---SS 435

  Fly   456 CFCVRFIAEHTK----MQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQA---PTLY 513
            ...::.:.:..|    .:.:..::|.:|:.|..::||..::.:.| :.:..|.::|.:   |.:.
 Worm   436 LMKIKVVLDDMKASIHAERELKRIKFEWQQVTRLIDRCIMFSYIL-ITIAFAMVMLASRDPPIVL 499

  Fly   514 DDRI 517
            :|.|
 Worm   500 NDLI 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 136/507 (27%)
Neur_chan_LBD 12..227 CDD:280998 76/215 (35%)
Neur_chan_memb 234..505 CDD:280999 59/284 (21%)
acr-18NP_506868.2 Neur_chan_LBD 33..237 CDD:280998 76/213 (36%)
Neur_chan_memb 244..486 CDD:280999 58/282 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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